Published Population Pharmacokinetic Models of Imatinib Perform Poorly on TDM Data from Pediatric Patients.

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Title: Published Population Pharmacokinetic Models of Imatinib Perform Poorly on TDM Data from Pediatric Patients.
Authors: Yang T; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Rasmussen ASB; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Weimann A; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Thastrup M; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Rank CU; Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Als-Nielsen B; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Malmros J; Childhood Cancer Unit, Karolinska University Hospital, and Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Wik HS; Department of Haematology, Oslo University Hospital Rikshospitalet, Oslo, Norway., Lohi O; TamCAM Center, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland., Overgaard U; Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Johannsdottir IMR; Department of Pediatric Hematology and Oncology, Rikshospitalet, Oslo University Hospital, Oslo, Norway., Vaitkeviciene G; Center for Pediatric Oncology and Hematology, Clinics for Children Diseases, Vilnius University, Vilnius, Lithuania., Dalhoff K; Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark., Schmiegelow K; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark., Lund TM; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. trine.lund@sund.ku.dk.; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark. trine.lund@sund.ku.dk.
Source: Targeted oncology [Target Oncol] 2025 Sep; Vol. 20 (5), pp. 871-886. Date of Electronic Publication: 2025 Sep 08.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Springer-Verlag France Country of Publication: France NLM ID: 101270595 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1776-260X (Electronic) Linking ISSN: 17762596 NLM ISO Abbreviation: Target Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1776-260X
DOI:10.1007/s11523-025-01172-2