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Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.

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Title: Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.
Authors: Huber LS; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Merline R; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Zeng-Brouwers J; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Vutukuri R; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Kraus N; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Ortiz C; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Guenther S; Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany., Buhl EM; Electron Microscopic Facility, RWTH Aachen University Hospital, Aachen, Germany., Hahnefeld L; Institute of Clinical Pharmacology, University Hospital Frankfurt, Frankfurt, Germany., Gurke R; Institute of Clinical Pharmacology, University Hospital Frankfurt, Frankfurt, Germany., Bein J; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt, Germany., Karimova M; Dr. Senckenberg Institute of Pathology, University Hospital, Frankfurt, Germany., Wurzel P; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Boor P; Electron Microscopic Facility, RWTH Aachen University Hospital, Aachen, Germany.; Georg Speyer Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany., Welsch C; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany., Wild P; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt, Germany., Pfeilschifter J; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany., Kögel D; Institute of Pathology, RWTH Aachen University, Aachen, Germany., Wygrecka M; Experimental Neurosurgery, University Hospital Frankfurt, Frankfurt, Germany.; Center for Infection and Genomics of the Lung (CIGL), Universities of Giessen and Marburg Lung Center, Giessen, Germany., Trebicka J; Institute of Lung Health, Giessen, Germany.; Department of Internal Medicine B, University Hospital Münster, Münster, Germany., Bartoszewski R; European Foundation for Study of Chronic Liver Failure, EF-Clif, Barcelona, Spain., Dikic I; Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland., Schaefer L; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.
Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2025 Nov 01; Vol. 329 (5), pp. C1360-C1379. Date of Electronic Publication: 2025 Sep 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.
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  Data: <searchLink fieldCode="AU" term="%22Huber+LS%22">Huber LS</searchLink>; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Merline+R%22">Merline R</searchLink>; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Zeng-Brouwers+J%22">Zeng-Brouwers J</searchLink>; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Vutukuri+R%22">Vutukuri R</searchLink>; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kraus+N%22">Kraus N</searchLink>; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Ortiz+C%22">Ortiz C</searchLink>; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Guenther+S%22">Guenther S</searchLink>; Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Buhl+EM%22">Buhl EM</searchLink>; Electron Microscopic Facility, RWTH Aachen University Hospital, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Hahnefeld+L%22">Hahnefeld L</searchLink>; Institute of Clinical Pharmacology, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Gurke+R%22">Gurke R</searchLink>; Institute of Clinical Pharmacology, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Bein+J%22">Bein J</searchLink>; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Karimova+M%22">Karimova M</searchLink>; Dr. Senckenberg Institute of Pathology, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Wurzel+P%22">Wurzel P</searchLink>; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Boor+P%22">Boor P</searchLink>; Electron Microscopic Facility, RWTH Aachen University Hospital, Aachen, Germany.; Georg Speyer Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Welsch+C%22">Welsch C</searchLink>; Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Wild+P%22">Wild P</searchLink>; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Pfeilschifter+J%22">Pfeilschifter J</searchLink>; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kögel+D%22">Kögel D</searchLink>; Institute of Pathology, RWTH Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Wygrecka+M%22">Wygrecka M</searchLink>; Experimental Neurosurgery, University Hospital Frankfurt, Frankfurt, Germany.; Center for Infection and Genomics of the Lung (CIGL), Universities of Giessen and Marburg Lung Center, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Trebicka+J%22">Trebicka J</searchLink>; Institute of Lung Health, Giessen, Germany.; Department of Internal Medicine B, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Bartoszewski+R%22">Bartoszewski R</searchLink>; European Foundation for Study of Chronic Liver Failure, EF-Clif, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Dikic+I%22">Dikic I</searchLink>; Department of Biophysics, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Schaefer+L%22">Schaefer L</searchLink>; Institute of Pharmacology and Toxicology, Goethe University Frankfurt, Frankfurt, Germany.
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  Data: <searchLink fieldCode="JN" term="%22100901225%22">American journal of physiology. Cell physiology</searchLink> [Am J Physiol Cell Physiol] 2025 Nov 01; Vol. 329 (5), pp. C1360-C1379. <i>Date of Electronic Publication: </i>2025 Sep 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Physiological+Society%22">American Physiological Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100901225 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-1563 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203636143%22">03636143 </searchLink><i>NLM ISO Abbreviation: </i>Am J Physiol Cell Physiol <i>Subsets: </i>MEDLINE
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