Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development.

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Title: Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development.
Authors: Rijal P; Chinese Academy of Medical Science Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom., Wei L; Chinese Academy of Medical Science Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom., Paesen GC; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Stuart DI; Chinese Academy of Medical Science Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Haworth M; Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom., Huang KA; Graduate Institute of Immunology and Department of Paediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.; Genomics Research Center, Academia Sinica, Taipei, Taiwan., Bowden TA; Division of Structural Biology, Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Townsend ARM; Chinese Academy of Medical Science Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Source: ELife [Elife] 2025 Sep 09; Vol. 14. Date of Electronic Publication: 2025 Sep 09.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2050-084X
DOI:10.7554/eLife.105317