Genetic variance in the murine defensin locus modulates glucose homeostasis.

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Title: Genetic variance in the murine defensin locus modulates glucose homeostasis.
Authors: Masson SWC; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia. stewart.masson@sydney.edu.au.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. stewart.masson@sydney.edu.au., Simpson RC; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; Melanoma Institute Australia, Sydney, NSW, Australia.; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Cutler HB; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Carlos PW; School of Chemistry, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Sydney, NSW, Australia., Marian OC; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Yau B; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Potter M; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Madsen S; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Cooke KC; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Craw NR; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Fuller OK; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Harney DJ; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Larance M; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Cooney GJ; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Morahan G; Centre for Diabetes Research, Harry Perkins Institute of Medical Research, Murdoch, WA, Australia., Shanahan ER; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Kebede MA; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Hodgkins C; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., Payne RJ; School of Chemistry, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Sydney, NSW, Australia., Stöckli J; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia., James DE; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia. david.james@sydney.edu.au.; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. david.james@sydney.edu.au.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. david.james@sydney.edu.au.
Source: The EMBO journal [EMBO J] 2025 Oct; Vol. 44 (20), pp. 5694-5711. Date of Electronic Publication: 2025 Sep 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-025-00555-5