Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells.

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Title: Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells.
Authors: McCastlain K; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Welsh C; Department of Mathematics & Computer Science, Rhodes College, Memphis, TN, USA., Ni Y; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Ding L; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chang TC; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Autry RJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Sejdiu BI; Center of Excellence for Data Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Pan Q; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Franco M; Biology Department, College of Sciences, Northeastern University, Boston, MA, USA., Chen W; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Wu H; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Gonzalez-Pena V; Department of Pediatrics, Stanford University, Stanford, CA, USA., Schreiner P; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Arunachalam S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Joo JH; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Brady S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Gawad C; Department of Pediatrics, Stanford University, Stanford, CA, USA., Evans WE; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Babu MM; Center of Excellence for Data Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Khrapko K; Biology Department, College of Sciences, Northeastern University, Boston, MA, USA., Yu J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wu G; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pounds S; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Kundu M; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Source: Science advances [Sci Adv] 2025 Sep 12; Vol. 11 (37), pp. eadt3873. Date of Electronic Publication: 2025 Sep 10.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.adt3873