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Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells.

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Title: Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells.
Authors: McCastlain K; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Welsh C; Department of Mathematics & Computer Science, Rhodes College, Memphis, TN, USA., Ni Y; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Ding L; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chang TC; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Autry RJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Sejdiu BI; Center of Excellence for Data Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Pan Q; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Franco M; Biology Department, College of Sciences, Northeastern University, Boston, MA, USA., Chen W; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Wu H; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Gonzalez-Pena V; Department of Pediatrics, Stanford University, Stanford, CA, USA., Schreiner P; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Arunachalam S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Joo JH; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Brady S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Gawad C; Department of Pediatrics, Stanford University, Stanford, CA, USA., Evans WE; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Babu MM; Center of Excellence for Data Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Khrapko K; Biology Department, College of Sciences, Northeastern University, Boston, MA, USA., Yu J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wu G; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pounds S; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Kundu M; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Source: Science advances [Sci Adv] 2025 Sep 12; Vol. 11 (37), pp. eadt3873. Date of Electronic Publication: 2025 Sep 10.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells.
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  Data: <searchLink fieldCode="AU" term="%22McCastlain+K%22">McCastlain K</searchLink>; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Welsh+C%22">Welsh C</searchLink>; Department of Mathematics & Computer Science, Rhodes College, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ni+Y%22">Ni Y</searchLink>; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ding+L%22">Ding L</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chang+TC%22">Chang TC</searchLink>; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Autry+RJ%22">Autry RJ</searchLink>; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sejdiu+BI%22">Sejdiu BI</searchLink>; Center of Excellence for Data Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Pan+Q%22">Pan Q</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Franco+M%22">Franco M</searchLink>; Biology Department, College of Sciences, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Pena+V%22">Gonzalez-Pena V</searchLink>; Department of Pediatrics, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schreiner+P%22">Schreiner P</searchLink>; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Arunachalam+S%22">Arunachalam S</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Joo+JH%22">Joo JH</searchLink>; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Brady+S%22">Brady S</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Gawad+C%22">Gawad C</searchLink>; Department of Pediatrics, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Evans+WE%22">Evans WE</searchLink>; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Babu+MM%22">Babu MM</searchLink>; Center of Excellence for Data Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Khrapko+K%22">Khrapko K</searchLink>; Biology Department, College of Sciences, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Wu+G%22">Wu G</searchLink>; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Pounds+S%22">Pounds S</searchLink>; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kundu+M%22">Kundu M</searchLink>; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
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