A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation.

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Title: A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation.
Authors: Kim W; Department of Biological Sciences, College of Natural Science, Seoul National University, Seoul 08826, South Korea., Kim S; Department of Biological Sciences, College of Natural Science, Seoul National University, Seoul 08826, South Korea., Woo H; Department of Biological Sciences, College of Natural Science, Seoul National University, Seoul 08826, South Korea., Jojare RA; Department of Biotechnology and Bioinformatics, Deogiri College, Dr.Babasaheb Ambedkar Marathwada University, Aurangabad, India., Mall R; Biotechnology Research Center, Technology Innovation Institute, P.O. Box:9639, Abu Dhabi, United Arab Emirates., Nicotra A; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, Université Claude Bernard Lyon 1, ENS de Lyon, Lyon, France., Py BF; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, Université Claude Bernard Lyon 1, ENS de Lyon, Lyon, France., Ngo C; Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Man SM; Division of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Patel CN; Biotechnology Research Center, Technology Innovation Institute, P.O. Box:9639, Abu Dhabi, United Arab Emirates; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA. Electronic address: chiragpatel269@gmail.com., Karki R; Department of Biological Sciences, College of Natural Science, Seoul National University, Seoul 08826, South Korea. Electronic address: rkarki@snu.ac.kr.
Source: Cell chemical biology [Cell Chem Biol] 2025 Sep 18; Vol. 32 (9), pp. 1125-1139.e7. Date of Electronic Publication: 2025 Sep 09.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2451-9448
DOI:10.1016/j.chembiol.2025.08.006