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ABCA7 variants impact phosphatidylcholine and mitochondria in neurons.

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Title: ABCA7 variants impact phosphatidylcholine and mitochondria in neurons.
Authors: von Maydell D; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Wright SE; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Pao PC; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Staab C; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., King O; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Spitaleri A; Department of Medical Biotechnologies and Translational Medicine, University of Milano, Milan, Italy., Bonner JM; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Liu L; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Yu CJ; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Chiu CC; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Leible D; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Ni Scannail A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Li M; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Boix CA; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mathys H; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Leclerc G; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA., Menchaca GS; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Welch G; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Graziosi A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Leary N; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Samaan G; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Kellis M; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.
Source: Nature [Nature] 2025 Nov; Vol. 647 (8089), pp. 462-471. Date of Electronic Publication: 2025 Sep 10.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Menchaca+GS%22">Menchaca GS</searchLink>; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Welch+G%22">Welch G</searchLink>; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Graziosi+A%22">Graziosi A</searchLink>; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Leary+N%22">Leary N</searchLink>; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Samaan+G%22">Samaan G</searchLink>; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kellis+M%22">Kellis M</searchLink>; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tsai+LH%22">Tsai LH</searchLink>; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.
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