Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins.
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| Title: | Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins. |
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| Authors: | Wade J; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Štrancar N; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Fernández-Quintero ML; Center for Molecular Biosciences Innsbruck, Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA, USA., Siebenhaar S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Jansen T; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Meier EPW; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Jenkins TP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Bjørn SP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Nguyen GTT; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Lomonte B; Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica., Gutiérrez JM; Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica., Sørensen CV; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark.; BioInnovation Institute, Copenhagen, Denmark., Loeffler JR; Center for Molecular Biosciences Innsbruck, Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, Austria.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA, USA., Paul A; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Tulika T; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Arnsdorf J; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Schoffelen S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Lundquist EVS; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Sørensen J; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA, USA., Voldborg BG; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Bohn MF; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Rivera-de-Torre E; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Morth JP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark., Laustsen AH; Department of Biotechnology and Biomedicine, Technical University of Denmark, Denmark. |
| Source: | MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2553624. Date of Electronic Publication: 2025 Sep 11. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1942-0870 |
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| DOI: | 10.1080/19420862.2025.2553624 |
