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Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models.

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Title: Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models.
Authors: Castelo Branco Ramos Nakandakari S; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil.; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States., Elliott EI; Department of Internal Medicine, Section of Infectious Diseases, Yale University, New Haven, Connecticut, United States.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States., Fudoli Lins Vieira R; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil., da Silva Rios T; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil., Fosam A; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States., Betim Pavan IC; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil., Maftoum Costa M; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil., Salvino da Silva LG; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil., de Oliveira Ramos C; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil., Rios Gonçalves G; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil., Akingbesote ND; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States., Sidarta-Oliveira D; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil., Moreli AP; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil., Rosseto Braga R; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil., Pinto AP; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil., Eisenstein A; Department of Immunobiology, Yale University, New Haven, Connecticut, United States., Velloso LA; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil., Simabuco FM; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil., Pauli JR; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil., Rochete Ropelle E; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil., Ramos da Silva AS; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil., Wang A; Department of Immunobiology, Yale University, New Haven, Connecticut, United States., Perry RJ; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States., Cintra DE; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil.; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
Source: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2025 Nov 01; Vol. 329 (5), pp. E663-E675. Date of Electronic Publication: 2025 Sep 12.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1522-1555
DOI:10.1152/ajpendo.00147.2025