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Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models.

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Title: Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models.
Authors: Castelo Branco Ramos Nakandakari S; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil.; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States., Elliott EI; Department of Internal Medicine, Section of Infectious Diseases, Yale University, New Haven, Connecticut, United States.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States., Fudoli Lins Vieira R; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil., da Silva Rios T; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil., Fosam A; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States., Betim Pavan IC; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil., Maftoum Costa M; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil., Salvino da Silva LG; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil., de Oliveira Ramos C; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil., Rios Gonçalves G; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil., Akingbesote ND; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States., Sidarta-Oliveira D; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil., Moreli AP; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil., Rosseto Braga R; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil., Pinto AP; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil., Eisenstein A; Department of Immunobiology, Yale University, New Haven, Connecticut, United States., Velloso LA; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil., Simabuco FM; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil., Pauli JR; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil., Rochete Ropelle E; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil., Ramos da Silva AS; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil., Wang A; Department of Immunobiology, Yale University, New Haven, Connecticut, United States., Perry RJ; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States., Cintra DE; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil.; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
Source: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2025 Nov 01; Vol. 329 (5), pp. E663-E675. Date of Electronic Publication: 2025 Sep 12.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE
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  Data: Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models.
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  Data: <searchLink fieldCode="AU" term="%22Castelo+Branco+Ramos+Nakandakari+S%22">Castelo Branco Ramos Nakandakari S</searchLink>; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil.; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States.<br /><searchLink fieldCode="AU" term="%22Elliott+EI%22">Elliott EI</searchLink>; Department of Internal Medicine, Section of Infectious Diseases, Yale University, New Haven, Connecticut, United States.; Department of Immunobiology, Yale University, New Haven, Connecticut, United States.<br /><searchLink fieldCode="AU" term="%22Fudoli+Lins+Vieira+R%22">Fudoli Lins Vieira R</searchLink>; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Rios+T%22">da Silva Rios T</searchLink>; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Fosam+A%22">Fosam A</searchLink>; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States.<br /><searchLink fieldCode="AU" term="%22Betim+Pavan+IC%22">Betim Pavan IC</searchLink>; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Maftoum+Costa+M%22">Maftoum Costa M</searchLink>; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Salvino+da+Silva+LG%22">Salvino da Silva LG</searchLink>; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+Ramos+C%22">de Oliveira Ramos C</searchLink>; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Rios+Gonçalves+G%22">Rios Gonçalves G</searchLink>; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Akingbesote+ND%22">Akingbesote ND</searchLink>; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States.<br /><searchLink fieldCode="AU" term="%22Sidarta-Oliveira+D%22">Sidarta-Oliveira D</searchLink>; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Moreli+AP%22">Moreli AP</searchLink>; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Rosseto+Braga+R%22">Rosseto Braga R</searchLink>; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.<br /><searchLink fieldCode="AU" term="%22Pinto+AP%22">Pinto AP</searchLink>; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Eisenstein+A%22">Eisenstein A</searchLink>; Department of Immunobiology, Yale University, New Haven, Connecticut, United States.<br /><searchLink fieldCode="AU" term="%22Velloso+LA%22">Velloso LA</searchLink>; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Simabuco+FM%22">Simabuco FM</searchLink>; School of Applied Sciences (FCA), Multidisciplinary Laboratory of Food and Health (LABMAS), University of Campinas (UNICAMP), Limeira, Brazil.; Department of Biochemistry, Applied Molecular Signaling Laboratory (LabSIMA), Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pauli+JR%22">Pauli JR</searchLink>; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Rochete+Ropelle+E%22">Rochete Ropelle E</searchLink>; School of Applied Sciences (FCA), Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, Brazil.; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Ramos+da+Silva+AS%22">Ramos da Silva AS</searchLink>; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Wang+A%22">Wang A</searchLink>; Department of Immunobiology, Yale University, New Haven, Connecticut, United States.<br /><searchLink fieldCode="AU" term="%22Perry+RJ%22">Perry RJ</searchLink>; Department of Internal Medicine, Endocrinology, Yale University, New Haven, Connecticut, United States.; Cellular and Molecular Physiology, Yale University, New Haven, Connecticut, United States.<br /><searchLink fieldCode="AU" term="%22Cintra+DE%22">Cintra DE</searchLink>; School of Applied Sciences (FCA), Laboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira, Brazil.; Nutritional Genomics and Lipids Research Center (CELN), Limeira, Brazil.; Obesity and Comorbidities Research Center (OCRC), Laboratory of Cell Signaling, University of Campinas, Campinas, Brazil.
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