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Fumarate hydratase ameliorates pressure overload induced cardiac remodeling by controlling Elovl7-mediated biosynthesis of unsaturated fatty acids.

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Title: Fumarate hydratase ameliorates pressure overload induced cardiac remodeling by controlling Elovl7-mediated biosynthesis of unsaturated fatty acids.
Authors: Li LL; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Sun CJ; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Mo XT; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Xing Y; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Zhang T; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Zhang H; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Zhao N; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China., Zeng XF; Cardiovascular Research Institute of Wuhan University, Wuhan, 430060, China., Wang SS; Cardiovascular Research Institute of Wuhan University, Wuhan, 430060, China., Meng YY; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. mengyan2293@whu.edu.cn.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. mengyan2293@whu.edu.cn., Xie SY; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. yangsai1995@whu.edu.cn.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. yangsai1995@whu.edu.cn., Deng W; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. vivideng1982@whu.edu.cn.; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, 430060, China. vivideng1982@whu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Feb; Vol. 47 (2), pp. 328-343. Date of Electronic Publication: 2025 Sep 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-7254
DOI:10.1038/s41401-025-01637-0