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Novel antitubercular agents based on 2,4-disubstituted 5-(aryl-2-ylmethyl)-5H-pyrrolo[3,2-d]pyrimidines.

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Title: Novel antitubercular agents based on 2,4-disubstituted 5-(aryl-2-ylmethyl)-5H-pyrrolo[3,2-d]pyrimidines.
Authors: Finger V; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic. Electronic address: vladimir.finger@fnhk.cz., Vrbicky M; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice 532 10, Czech Republic., Muckova L; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic., Prchal L; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Novak M; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Marek J; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Soukup O; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Hympanova M; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Sorf A; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic., Benkova M; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Bartacek J; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice 532 10, Czech Republic., Drabina P; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice 532 10, Czech Republic., Kufa M; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Kovar O; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Fikejzlová L; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic., Hruby M; Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského náměstí 2, Prague 6 162 00, Czech Republic., Ozhelevska O; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Jagob J; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Zdarova-Karasova J; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic., Odvarkova J; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic., Kaderavková I; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic., Rozsypal T; Nuclear, Biological and Chemical Defence Institute, University of Defence, Vita Nejedleho 1, 68201 Vyskov, Czech Republic., Ewa Greber K; Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Aleja Generała Józefa Hallera 107, 80-416 Gdansk, Poland., Ciura K; Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Aleja Generała Józefa Hallera 107, 80-416 Gdansk, Poland; Laboratory of Environmental Chemoinformatics, Faculty of Chemistry, University of, Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland., Janousek J; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic., Kratky M; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic., Igreja Sa IC; Institute of Clinical Microbiology, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove 50003, Czech Republic., Bostik P; Institute of Clinical Microbiology, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove 50003, Czech Republic; Institute of Clinical Microbiology, University Hospital, Sokolska 581, Hradec Kralove 50005, Czech Republic., Sleha R; Institute of Clinical Microbiology, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove 50003, Czech Republic., Roh J; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic., Korabecny J; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic. Electronic address: jan.korabecny@fnhk.cz.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Oct; Vol. 191, pp. 118537. Date of Electronic Publication: 2025 Sep 12.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
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  Data: Novel antitubercular agents based on 2,4-disubstituted 5-(aryl-2-ylmethyl)-5H-pyrrolo[3,2-d]pyrimidines.
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  Data: <searchLink fieldCode="AU" term="%22Finger+V%22">Finger V</searchLink>; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic. Electronic address: vladimir.finger@fnhk.cz.<br /><searchLink fieldCode="AU" term="%22Vrbicky+M%22">Vrbicky M</searchLink>; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice 532 10, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Muckova+L%22">Muckova L</searchLink>; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Prchal+L%22">Prchal L</searchLink>; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Novak+M%22">Novak M</searchLink>; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Marek+J%22">Marek J</searchLink>; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Soukup+O%22">Soukup O</searchLink>; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hympanova+M%22">Hympanova M</searchLink>; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Sorf+A%22">Sorf A</searchLink>; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Benkova+M%22">Benkova M</searchLink>; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Bartacek+J%22">Bartacek J</searchLink>; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice 532 10, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Drabina+P%22">Drabina P</searchLink>; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentská 573, Pardubice 532 10, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kufa+M%22">Kufa M</searchLink>; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kovar+O%22">Kovar O</searchLink>; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Fikejzlová+L%22">Fikejzlová L</searchLink>; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hruby+M%22">Hruby M</searchLink>; Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského náměstí 2, Prague 6 162 00, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Ozhelevska+O%22">Ozhelevska O</searchLink>; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Jagob+J%22">Jagob J</searchLink>; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Zdarova-Karasova+J%22">Zdarova-Karasova J</searchLink>; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Odvarkova+J%22">Odvarkova J</searchLink>; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kaderavková+I%22">Kaderavková I</searchLink>; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Rozsypal+T%22">Rozsypal T</searchLink>; Nuclear, Biological and Chemical Defence Institute, University of Defence, Vita Nejedleho 1, 68201 Vyskov, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Ewa+Greber+K%22">Ewa Greber K</searchLink>; Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Aleja Generała Józefa Hallera 107, 80-416 Gdansk, Poland.<br /><searchLink fieldCode="AU" term="%22Ciura+K%22">Ciura K</searchLink>; Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Aleja Generała Józefa Hallera 107, 80-416 Gdansk, Poland; Laboratory of Environmental Chemoinformatics, Faculty of Chemistry, University of, Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.<br /><searchLink fieldCode="AU" term="%22Janousek+J%22">Janousek J</searchLink>; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kratky+M%22">Kratky M</searchLink>; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Igreja+Sa+IC%22">Igreja Sa IC</searchLink>; Institute of Clinical Microbiology, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove 50003, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Bostik+P%22">Bostik P</searchLink>; Institute of Clinical Microbiology, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove 50003, Czech Republic; Institute of Clinical Microbiology, University Hospital, Sokolska 581, Hradec Kralove 50005, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Sleha+R%22">Sleha R</searchLink>; Institute of Clinical Microbiology, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove 50003, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Roh+J%22">Roh J</searchLink>; Department of Organic and Bioorganic Chemistry, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University, Akademika Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Korabecny+J%22">Korabecny J</searchLink>; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic; Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove 500 01, Czech Republic. Electronic address: jan.korabecny@fnhk.cz.
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