Ascorbate mitigates oxidative stress and hemin cytotoxicity in heme oxygenase-1 deficiency.

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Title: Ascorbate mitigates oxidative stress and hemin cytotoxicity in heme oxygenase-1 deficiency.
Authors: Berendes LS; Department of General Pediatrics, University Hospital Münster, Münster, Germany., Schulze Westhoff P; Department of General Pediatrics, University Hospital Münster, Münster, Germany., Tobinski AM; Department of Neurology, University Hospital Münster, Münster, Germany., Narvaez Pardo JA; Department of General Pediatrics, Laboratory of Clinical Biochemistry and Metabolism, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Wingert V; Department of General Pediatrics, Laboratory of Clinical Biochemistry and Metabolism, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Fobker M; Center for Laboratory Medicine, University Hospital Münster, Münster, Germany., Biskup S; CeGAT and Center for Human Genetics, Tübingen, Germany., Seelhöfer A; Department of General Pediatrics, University Hospital Münster, Münster, Germany., Van Marck V; Department of Pathology, University Hospital Münster, Münster, Germany., Heitplatz B; Department of Pathology, University Hospital Münster, Münster, Germany., Drell PT; Department of General Pediatrics, University Hospital Münster, Münster, Germany., Wittkowski H; Department of Pediatric Rheumatology & Immunology, University Hospital Münster, Münster, Germany., Das AM; Department of Pediatrics, Pediatric Metabolic Medicine, Hannover Medical School, Hannover, Germany., Hannibal L; Department of General Pediatrics, Laboratory of Clinical Biochemistry and Metabolism, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Nowak WN; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; August Chełkowski Institute of Physics, University of Silesia, Chorzów, Poland., Józkowicz A; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland., Klotz L; Department of Neurology, University Hospital Münster, Münster, Germany., Varga G; Department of Pediatric Rheumatology & Immunology, University Hospital Münster, Münster, Germany., Marquardt T; Department of General Pediatrics, University Hospital Münster, Münster, Germany., Park J; Department of General Pediatrics, University Hospital Münster, Münster, Germany. Electronic address: julien.park@ukmuenster.de.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Nov; Vol. 301 (11), pp. 110705. Date of Electronic Publication: 2025 Sep 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1083-351X
DOI:10.1016/j.jbc.2025.110705