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Ascorbate mitigates oxidative stress and hemin cytotoxicity in heme oxygenase-1 deficiency.

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Title: Ascorbate mitigates oxidative stress and hemin cytotoxicity in heme oxygenase-1 deficiency.
Authors: Berendes LS; Department of General Pediatrics, University Hospital Münster, Münster, Germany., Schulze Westhoff P; Department of General Pediatrics, University Hospital Münster, Münster, Germany., Tobinski AM; Department of Neurology, University Hospital Münster, Münster, Germany., Narvaez Pardo JA; Department of General Pediatrics, Laboratory of Clinical Biochemistry and Metabolism, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Wingert V; Department of General Pediatrics, Laboratory of Clinical Biochemistry and Metabolism, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Fobker M; Center for Laboratory Medicine, University Hospital Münster, Münster, Germany., Biskup S; CeGAT and Center for Human Genetics, Tübingen, Germany., Seelhöfer A; Department of General Pediatrics, University Hospital Münster, Münster, Germany., Van Marck V; Department of Pathology, University Hospital Münster, Münster, Germany., Heitplatz B; Department of Pathology, University Hospital Münster, Münster, Germany., Drell PT; Department of General Pediatrics, University Hospital Münster, Münster, Germany., Wittkowski H; Department of Pediatric Rheumatology & Immunology, University Hospital Münster, Münster, Germany., Das AM; Department of Pediatrics, Pediatric Metabolic Medicine, Hannover Medical School, Hannover, Germany., Hannibal L; Department of General Pediatrics, Laboratory of Clinical Biochemistry and Metabolism, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Nowak WN; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; August Chełkowski Institute of Physics, University of Silesia, Chorzów, Poland., Józkowicz A; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland., Klotz L; Department of Neurology, University Hospital Münster, Münster, Germany., Varga G; Department of Pediatric Rheumatology & Immunology, University Hospital Münster, Münster, Germany., Marquardt T; Department of General Pediatrics, University Hospital Münster, Münster, Germany., Park J; Department of General Pediatrics, University Hospital Münster, Münster, Germany. Electronic address: julien.park@ukmuenster.de.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Nov; Vol. 301 (11), pp. 110705. Date of Electronic Publication: 2025 Sep 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ascorbate mitigates oxidative stress and hemin cytotoxicity in heme oxygenase-1 deficiency.
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  Data: <searchLink fieldCode="AU" term="%22Berendes+LS%22">Berendes LS</searchLink>; Department of General Pediatrics, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+Westhoff+P%22">Schulze Westhoff P</searchLink>; Department of General Pediatrics, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Tobinski+AM%22">Tobinski AM</searchLink>; Department of Neurology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Narvaez+Pardo+JA%22">Narvaez Pardo JA</searchLink>; Department of General Pediatrics, Laboratory of Clinical Biochemistry and Metabolism, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wingert+V%22">Wingert V</searchLink>; Department of General Pediatrics, Laboratory of Clinical Biochemistry and Metabolism, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fobker+M%22">Fobker M</searchLink>; Center for Laboratory Medicine, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Biskup+S%22">Biskup S</searchLink>; CeGAT and Center for Human Genetics, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Seelhöfer+A%22">Seelhöfer A</searchLink>; Department of General Pediatrics, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Van+Marck+V%22">Van Marck V</searchLink>; Department of Pathology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Heitplatz+B%22">Heitplatz B</searchLink>; Department of Pathology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Drell+PT%22">Drell PT</searchLink>; Department of General Pediatrics, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Wittkowski+H%22">Wittkowski H</searchLink>; Department of Pediatric Rheumatology & Immunology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Das+AM%22">Das AM</searchLink>; Department of Pediatrics, Pediatric Metabolic Medicine, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hannibal+L%22">Hannibal L</searchLink>; Department of General Pediatrics, Laboratory of Clinical Biochemistry and Metabolism, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Nowak+WN%22">Nowak WN</searchLink>; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; August Chełkowski Institute of Physics, University of Silesia, Chorzów, Poland.<br /><searchLink fieldCode="AU" term="%22Józkowicz+A%22">Józkowicz A</searchLink>; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Klotz+L%22">Klotz L</searchLink>; Department of Neurology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Varga+G%22">Varga G</searchLink>; Department of Pediatric Rheumatology & Immunology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Marquardt+T%22">Marquardt T</searchLink>; Department of General Pediatrics, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Department of General Pediatrics, University Hospital Münster, Münster, Germany. Electronic address: julien.park@ukmuenster.de.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Nov; Vol. 301 (11), pp. 110705. <i>Date of Electronic Publication: </i>2025 Sep 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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