Tau, amyloid-β and α-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology.

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Title: Tau, amyloid-β and α-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology.
Authors: Webster JM; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Yang YT; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Miller AT; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Zane A; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Scholz K; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Stone WJ; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Mudium N; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Corbin-Stein NJ; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Won WJ; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Stoll AC; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Greathouse KM; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Cooper NH; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Long LF; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Manuel PN; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Herskowitz JH; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Yacoubian TA; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Tyrrell DJ; University of Alabama at Birmingham, Department of Pathology, Division of Molecular and Cellular Pathology, Birmingham, AL, 35294., Sandoval IM; Barrow Neurological Institute, Department of Translational Neuroscience; Phoenix, AZ, 85013., Manfredsson FP; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.; Barrow Neurological Institute, Department of Translational Neuroscience; Phoenix, AZ, 85013., Kordower JH; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.; Arizona State University, ASU-Banner Neurodegenerative Disease Research Center, Bio-design Institute, Tempe, AZ, 85281., Harms AS; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 24. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2024.10.13.618101