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Tau, amyloid-β and α-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology.

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Title: Tau, amyloid-β and α-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology.
Authors: Webster JM; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Yang YT; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Miller AT; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Zane A; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Scholz K; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Stone WJ; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Mudium N; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Corbin-Stein NJ; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Won WJ; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Stoll AC; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Greathouse KM; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Cooper NH; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Long LF; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Manuel PN; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Herskowitz JH; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Yacoubian TA; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294., Tyrrell DJ; University of Alabama at Birmingham, Department of Pathology, Division of Molecular and Cellular Pathology, Birmingham, AL, 35294., Sandoval IM; Barrow Neurological Institute, Department of Translational Neuroscience; Phoenix, AZ, 85013., Manfredsson FP; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.; Barrow Neurological Institute, Department of Translational Neuroscience; Phoenix, AZ, 85013., Kordower JH; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.; Arizona State University, ASU-Banner Neurodegenerative Disease Research Center, Bio-design Institute, Tempe, AZ, 85281., Harms AS; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 24. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
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IllustrationInfo
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  Data: Tau, amyloid-β and α-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology.
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  Data: <searchLink fieldCode="AU" term="%22Webster+JM%22">Webster JM</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.<br /><searchLink fieldCode="AU" term="%22Yang+YT%22">Yang YT</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.<br /><searchLink fieldCode="AU" term="%22Miller+AT%22">Miller AT</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Zane+A%22">Zane A</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Scholz+K%22">Scholz K</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Stone+WJ%22">Stone WJ</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Mudium+N%22">Mudium N</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Corbin-Stein+NJ%22">Corbin-Stein NJ</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.<br /><searchLink fieldCode="AU" term="%22Won+WJ%22">Won WJ</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Stoll+AC%22">Stoll AC</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Greathouse+KM%22">Greathouse KM</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Cooper+NH%22">Cooper NH</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Long+LF%22">Long LF</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Manuel+PN%22">Manuel PN</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Herskowitz+JH%22">Herskowitz JH</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Yacoubian+TA%22">Yacoubian TA</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Tyrrell+DJ%22">Tyrrell DJ</searchLink>; University of Alabama at Birmingham, Department of Pathology, Division of Molecular and Cellular Pathology, Birmingham, AL, 35294.<br /><searchLink fieldCode="AU" term="%22Sandoval+IM%22">Sandoval IM</searchLink>; Barrow Neurological Institute, Department of Translational Neuroscience; Phoenix, AZ, 85013.<br /><searchLink fieldCode="AU" term="%22Manfredsson+FP%22">Manfredsson FP</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.; Barrow Neurological Institute, Department of Translational Neuroscience; Phoenix, AZ, 85013.<br /><searchLink fieldCode="AU" term="%22Kordower+JH%22">Kordower JH</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.; Arizona State University, ASU-Banner Neurodegenerative Disease Research Center, Bio-design Institute, Tempe, AZ, 85281.<br /><searchLink fieldCode="AU" term="%22Harms+AS%22">Harms AS</searchLink>; University of Alabama at Birmingham, Department of Neurology, Killion Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL, 35294.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.
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        Value: 10.1101/2024.10.13.618101
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              Text: 2025 Nov 24
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