Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer's Disease Model.

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Title: Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer's Disease Model.
Authors: Jhaldiyal A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA., Kumari M; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Tripathi T; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Khan MR; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Passed away prior to completion of the manuscript., Wang J; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Guttman L; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA., Biswas D; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Pasupuleti A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Aggarwal A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Pandya S; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Chou SC; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA., Panicker N; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Present Address: Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Monghekar A; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Albert M; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Bekris LM; Department of Laboratory Medicine and Pathology, University of Washington, Harborview Research and Training Building, 300 Ninth Ave, Box 359665, Seattle, WA 98104.; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH 44195, USA., Leverenz JB; Lou Ruvo Center for Brain Health, Neurological Institute, and Department of Neurology, Cleveland Clinic, Cleveland, OH 44195, USA.; Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System (S-182), 1660 South Columbian Way, Seattle, WA 98108, USA.; Department of Neurology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA., Kam TI; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Present Address: Department of Brain and Cognitive Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.; Present Address: Graduate School of Stem Cell and Regenerative Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea., Dawson TM; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Lead Contact., Dawson VL; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 07. Date of Electronic Publication: 2025 Sep 07.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.09.06.674313