Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer's Disease Model.
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| Title: | Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer's Disease Model. |
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| Authors: | Jhaldiyal A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA., Kumari M; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Tripathi T; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA., Khan MR; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Passed away prior to completion of the manuscript., Wang J; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Guttman L; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA., Biswas D; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Pasupuleti A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Aggarwal A; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Pandya S; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Chou SC; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA., Panicker N; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Present Address: Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA., Monghekar A; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Albert M; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Bekris LM; Department of Laboratory Medicine and Pathology, University of Washington, Harborview Research and Training Building, 300 Ninth Ave, Box 359665, Seattle, WA 98104.; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH 44195, USA., Leverenz JB; Lou Ruvo Center for Brain Health, Neurological Institute, and Department of Neurology, Cleveland Clinic, Cleveland, OH 44195, USA.; Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System (S-182), 1660 South Columbian Way, Seattle, WA 98108, USA.; Department of Neurology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA., Kam TI; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Present Address: Department of Brain and Cognitive Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.; Present Address: Graduate School of Stem Cell and Regenerative Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea., Dawson TM; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Lead Contact., Dawson VL; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 07. Date of Electronic Publication: 2025 Sep 07. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40950202 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer's Disease Model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Jhaldiyal+A%22">Jhaldiyal A</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.<br /><searchLink fieldCode="AU" term="%22Kumari+M%22">Kumari M</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Tripathi+T%22">Tripathi T</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.<br /><searchLink fieldCode="AU" term="%22Khan+MR%22">Khan MR</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Passed away prior to completion of the manuscript.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Guttman+L%22">Guttman L</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.<br /><searchLink fieldCode="AU" term="%22Biswas+D%22">Biswas D</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Pasupuleti+A%22">Pasupuleti A</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Aggarwal+A%22">Aggarwal A</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Pandya+S%22">Pandya S</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Chou+SC%22">Chou SC</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.<br /><searchLink fieldCode="AU" term="%22Panicker+N%22">Panicker N</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Present Address: Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Monghekar+A%22">Monghekar A</searchLink>; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Albert+M%22">Albert M</searchLink>; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.<br /><searchLink fieldCode="AU" term="%22Bekris+LM%22">Bekris LM</searchLink>; Department of Laboratory Medicine and Pathology, University of Washington, Harborview Research and Training Building, 300 Ninth Ave, Box 359665, Seattle, WA 98104.; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.<br /><searchLink fieldCode="AU" term="%22Leverenz+JB%22">Leverenz JB</searchLink>; Lou Ruvo Center for Brain Health, Neurological Institute, and Department of Neurology, Cleveland Clinic, Cleveland, OH 44195, USA.; Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System (S-182), 1660 South Columbian Way, Seattle, WA 98108, USA.; Department of Neurology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Kam+TI%22">Kam TI</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Present Address: Department of Brain and Cognitive Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.; Present Address: Graduate School of Stem Cell and Regenerative Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Dawson+TM%22">Dawson TM</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Lead Contact.<br /><searchLink fieldCode="AU" term="%22Dawson+VL%22">Dawson VL</searchLink>; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Department of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.; Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Sep 07. <i>Date of Electronic Publication: </i>2025 Sep 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2025.09.06.674313 Languages: – Code: eng Text: English Titles: – TitleFull: Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer's Disease Model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jhaldiyal A – PersonEntity: Name: NameFull: Kumari M – PersonEntity: Name: NameFull: Tripathi T – PersonEntity: Name: NameFull: Khan MR – PersonEntity: Name: NameFull: Wang J – PersonEntity: Name: NameFull: Guttman L – PersonEntity: Name: NameFull: Biswas D – PersonEntity: Name: NameFull: Pasupuleti A – PersonEntity: Name: NameFull: Aggarwal A – PersonEntity: Name: NameFull: Pandya S – PersonEntity: Name: NameFull: Chou SC – PersonEntity: Name: NameFull: Panicker N – PersonEntity: Name: NameFull: Monghekar A – PersonEntity: Name: NameFull: Albert M – PersonEntity: Name: NameFull: Bekris LM – PersonEntity: Name: NameFull: Leverenz JB – PersonEntity: Name: NameFull: Kam TI – PersonEntity: Name: NameFull: Dawson TM – PersonEntity: Name: NameFull: Dawson VL IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 09 Text: 2025 Sep 07 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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