Metabolic Dysregulation of 27-Hydroxycholesterol Sensitizes Proximal Tubular Epithelial Cells to Ferroptosis in Ischemic Acute Kidney Injury.

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Title: Metabolic Dysregulation of 27-Hydroxycholesterol Sensitizes Proximal Tubular Epithelial Cells to Ferroptosis in Ischemic Acute Kidney Injury.
Authors: Zhang YL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Li XY; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Tang TT; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Yang Q; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Wang B; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Li ZL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Wen Y; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Wu QL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Lv LL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Feng Y; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.; Department of Medicine, Icahn School of Medicine at Mount Sinai, Division of Nephrology, New York, New York., Ruan XZ; Key Laboratory of Molecular Biology on Infectious Diseases, Centre for Lipid Research, Ministry of Education, Chongqing Medical University, Chongqing, China., He JC; Department of Medicine, Icahn School of Medicine at Mount Sinai, Division of Nephrology, New York, New York., Wang B; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Liu BC; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Source: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2026 Mar 01; Vol. 37 (3), pp. 445-459. Date of Electronic Publication: 2025 Sep 15.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health, on behalf of the American Society of Nephrology Country of Publication: United States NLM ID: 9013836 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-3450 (Electronic) Linking ISSN: 10466673 NLM ISO Abbreviation: J Am Soc Nephrol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:1533-3450
DOI:10.1681/ASN.0000000857