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Metabolic Dysregulation of 27-Hydroxycholesterol Sensitizes Proximal Tubular Epithelial Cells to Ferroptosis in Ischemic Acute Kidney Injury.

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Title: Metabolic Dysregulation of 27-Hydroxycholesterol Sensitizes Proximal Tubular Epithelial Cells to Ferroptosis in Ischemic Acute Kidney Injury.
Authors: Zhang YL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Li XY; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Tang TT; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Yang Q; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Wang B; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Li ZL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Wen Y; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Wu QL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Lv LL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Feng Y; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.; Department of Medicine, Icahn School of Medicine at Mount Sinai, Division of Nephrology, New York, New York., Ruan XZ; Key Laboratory of Molecular Biology on Infectious Diseases, Centre for Lipid Research, Ministry of Education, Chongqing Medical University, Chongqing, China., He JC; Department of Medicine, Icahn School of Medicine at Mount Sinai, Division of Nephrology, New York, New York., Wang B; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China., Liu BC; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Source: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2026 Mar 01; Vol. 37 (3), pp. 445-459. Date of Electronic Publication: 2025 Sep 15.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health, on behalf of the American Society of Nephrology Country of Publication: United States NLM ID: 9013836 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-3450 (Electronic) Linking ISSN: 10466673 NLM ISO Abbreviation: J Am Soc Nephrol Subsets: MEDLINE; In Process
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  Data: <searchLink fieldCode="AU" term="%22Zhang+YL%22">Zhang YL</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Li+XY%22">Li XY</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Tang+TT%22">Tang TT</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Yang+Q%22">Yang Q</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Li+ZL%22">Li ZL</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wen+Y%22">Wen Y</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wu+QL%22">Wu QL</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Lv+LL%22">Lv LL</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.; Department of Medicine, Icahn School of Medicine at Mount Sinai, Division of Nephrology, New York, New York.<br /><searchLink fieldCode="AU" term="%22Ruan+XZ%22">Ruan XZ</searchLink>; Key Laboratory of Molecular Biology on Infectious Diseases, Centre for Lipid Research, Ministry of Education, Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22He+JC%22">He JC</searchLink>; Department of Medicine, Icahn School of Medicine at Mount Sinai, Division of Nephrology, New York, New York.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Liu+BC%22">Liu BC</searchLink>; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
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  Data: <searchLink fieldCode="JN" term="%229013836%22">Journal of the American Society of Nephrology : JASN</searchLink> [J Am Soc Nephrol] 2026 Mar 01; Vol. 37 (3), pp. 445-459. <i>Date of Electronic Publication: </i>2025 Sep 15.
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              Text: 2026 Mar 01
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