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SAR Studies around the SULT1A1-Activated Alkylator YC-1 as Cytotoxic Agents against Biliary Tract Cancer Cells.

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Title: SAR Studies around the SULT1A1-Activated Alkylator YC-1 as Cytotoxic Agents against Biliary Tract Cancer Cells.
Authors: Kong K; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Zhao W; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Shrimp JH; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Vava M; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Sinha R; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Sharma S; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Lee TD; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Roth JS; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Lee OW; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Lewis D; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Kearney SE; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Rohde JM; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Davis MI; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Shah P; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Wang AQ; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Xu X; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Shi L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, United States., Shen M; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Boxer MB; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Bardeesy N; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, United States., Hall MD; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States., Patnaik S; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Sep 25; Vol. 68 (18), pp. 18885-18907. Date of Electronic Publication: 2025 Sep 16.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SAR Studies around the SULT1A1-Activated Alkylator YC-1 as Cytotoxic Agents against Biliary Tract Cancer Cells.
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  Data: <searchLink fieldCode="AU" term="%22Kong+K%22">Kong K</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Shrimp+JH%22">Shrimp JH</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Vava+M%22">Vava M</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Sinha+R%22">Sinha R</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Lee+TD%22">Lee TD</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Roth+JS%22">Roth JS</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Lee+OW%22">Lee OW</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Lewis+D%22">Lewis D</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Kearney+SE%22">Kearney SE</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Rohde+JM%22">Rohde JM</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Davis+MI%22">Davis MI</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Shah+P%22">Shah P</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Wang+AQ%22">Wang AQ</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Shi+L%22">Shi L</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, United States.<br /><searchLink fieldCode="AU" term="%22Shen+M%22">Shen M</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Boxer+MB%22">Boxer MB</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Bardeesy+N%22">Bardeesy N</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, United States.<br /><searchLink fieldCode="AU" term="%22Hall+MD%22">Hall MD</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.<br /><searchLink fieldCode="AU" term="%22Patnaik+S%22">Patnaik S</searchLink>; National Center for Advancing Translational Science, National Institute of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Sep 25; Vol. 68 (18), pp. 18885-18907. <i>Date of Electronic Publication: </i>2025 Sep 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.5c00489
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        Text: English
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      – TitleFull: SAR Studies around the SULT1A1-Activated Alkylator YC-1 as Cytotoxic Agents against Biliary Tract Cancer Cells.
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              Text: 2025 Sep 25
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