Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype.

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Title: Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype.
Authors: Miller ZA; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Ossenkoppele R; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Clinical Memory Research Unit, Skånes universitetssjukhus, VE Minnessjukdomar, Lund University, Malmö, Sweden., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Allen IE; Department of Biostatistics, University of California San Francisco, San Francisco, California, USA., Shwe W; School of Medicine, George Washington University, Washington, District of Columbia, USA., Rosenberg L; Department of Medicine Pediatrics, University of Colorado, Boulder, Colorado, USA., Olguin DJ; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Erkkinen MG; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Butler PM; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Spina S; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Yokoyama JS; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Desikan RS; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Scheltens P; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., van der Flier W; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Pijnenburg Y; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Wolters E; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Rademakers R; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.; Department of Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, Wilrijk, Belgium., Geschwind DH; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, USA., Kramer JH; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Rosen HJ; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Rankin KP; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Grinberg LT; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.; Department of Pathology, University of California San Francisco, San Francisco, California, USA., Seeley WW; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.; Department of Pathology, University of California San Francisco, San Francisco, California, USA., Sturm V; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Perry DC; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Miller BL; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA., Rabinovici GD; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA., Gorno-Tempini ML; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Sep; Vol. 21 (9), pp. e70668.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1552-5279
DOI:10.1002/alz.70668