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UHPLC-QTOF-MS/MS metabolomic profiling and in silico-invivo evaluation of Gliricidia sepium leaves for renoprotection in diabetic nephropathy.

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Title: UHPLC-QTOF-MS/MS metabolomic profiling and in silico-invivo evaluation of Gliricidia sepium leaves for renoprotection in diabetic nephropathy.
Authors: Wafaey AA; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt. Electronic address: aya.wafaey@pharma.cu.edu.eg., El-Hawary SS; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt., El Raey MA; Phytochemistry & Plant Systematic Department, National Research Centre, El Buhouth St., Dokki, Cairo 12622, Egypt., Abdelrahman SS; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt., Ali AM; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt., Mandour YM; School of Life and Medical Sciences, University of Hertfordshire hosted by Global Academic Foundation, New Administrative Capital, 11578 Cairo, Egypt., Fayek FH; Pharmaceutical Chemistry Department, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, 11786 Cairo, Egypt., Mohamed SS; Department of Nutrition and Food Science, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt., El-Rashedy AA; Natural and Microbial Products Department, National Research Center, 33 El Bohouth St., Dokki, Giza 12622, Egypt., Mohamed OG; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt; Natural Products Discovery Core, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA., Kirollos FN; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt., Abdelhameed MF; Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St., Dokki, Cairo 12622, Egypt.
Source: Fitoterapia [Fitoterapia] 2025 Oct; Vol. 186, pp. 106875. Date of Electronic Publication: 2025 Sep 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE
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  Data: UHPLC-QTOF-MS/MS metabolomic profiling and in silico-invivo evaluation of Gliricidia sepium leaves for renoprotection in diabetic nephropathy.
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  Data: <searchLink fieldCode="AU" term="%22Wafaey+AA%22">Wafaey AA</searchLink>; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt. Electronic address: aya.wafaey@pharma.cu.edu.eg.<br /><searchLink fieldCode="AU" term="%22El-Hawary+SS%22">El-Hawary SS</searchLink>; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22El+Raey+MA%22">El Raey MA</searchLink>; Phytochemistry & Plant Systematic Department, National Research Centre, El Buhouth St., Dokki, Cairo 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelrahman+SS%22">Abdelrahman SS</searchLink>; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.<br /><searchLink fieldCode="AU" term="%22Ali+AM%22">Ali AM</searchLink>; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.<br /><searchLink fieldCode="AU" term="%22Mandour+YM%22">Mandour YM</searchLink>; School of Life and Medical Sciences, University of Hertfordshire hosted by Global Academic Foundation, New Administrative Capital, 11578 Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Fayek+FH%22">Fayek FH</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, 11786 Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohamed+SS%22">Mohamed SS</searchLink>; Department of Nutrition and Food Science, National Research Centre, 33 El Bohouth St., Dokki, Giza 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Rashedy+AA%22">El-Rashedy AA</searchLink>; Natural and Microbial Products Department, National Research Center, 33 El Bohouth St., Dokki, Giza 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohamed+OG%22">Mohamed OG</searchLink>; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt; Natural Products Discovery Core, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Kirollos+FN%22">Kirollos FN</searchLink>; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelhameed+MF%22">Abdelhameed MF</searchLink>; Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Bohouth St., Dokki, Cairo 12622, Egypt.
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  Data: <searchLink fieldCode="JN" term="%2216930290R%22">Fitoterapia</searchLink> [Fitoterapia] 2025 Oct; Vol. 186, pp. 106875. <i>Date of Electronic Publication: </i>2025 Sep 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>16930290R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-6971 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220367326X%22">0367326X </searchLink><i>NLM ISO Abbreviation: </i>Fitoterapia <i>Subsets: </i>MEDLINE
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