Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.

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Title: Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.
Authors: Hassan O; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Pizzagalli M; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Leary OP; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Zepecki JP; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Corseri A; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Wu LJ; Therapeutic Sciences Graduate Program, Brown University, Providence, Rhode Island, USA., Sasipalli S; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Lee D; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Hayward L; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Tran L; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Fajardo E; Department of Computational and Systems Biology, Albert Einstein College of Medicine, Bronx, New York, USA., Fiser A; Department of Computational and Systems Biology, Albert Einstein College of Medicine, Bronx, New York, USA., Karambizi D; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Tapinos N; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA; Department of Neurosurgery, Brown University Health, Providence, Rhode Island, USA; Brown RNA Center, Brown University, Providence, Rhode Island, USA. Electronic address: nikos@homerbio.com.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110732. Date of Electronic Publication: 2025 Sep 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1083-351X
DOI:10.1016/j.jbc.2025.110732