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Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.

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Title: Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.
Authors: Hassan O; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Pizzagalli M; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Leary OP; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Zepecki JP; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Corseri A; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Wu LJ; Therapeutic Sciences Graduate Program, Brown University, Providence, Rhode Island, USA., Sasipalli S; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Lee D; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Hayward L; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Tran L; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Fajardo E; Department of Computational and Systems Biology, Albert Einstein College of Medicine, Bronx, New York, USA., Fiser A; Department of Computational and Systems Biology, Albert Einstein College of Medicine, Bronx, New York, USA., Karambizi D; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA., Tapinos N; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA; Department of Neurosurgery, Brown University Health, Providence, Rhode Island, USA; Brown RNA Center, Brown University, Providence, Rhode Island, USA. Electronic address: nikos@homerbio.com.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110732. Date of Electronic Publication: 2025 Sep 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Hassan+O%22">Hassan O</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Pizzagalli+M%22">Pizzagalli M</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Leary+OP%22">Leary OP</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Zepecki+JP%22">Zepecki JP</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Corseri+A%22">Corseri A</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Wu+LJ%22">Wu LJ</searchLink>; Therapeutic Sciences Graduate Program, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Sasipalli+S%22">Sasipalli S</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Lee+D%22">Lee D</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Hayward+L%22">Hayward L</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Tran+L%22">Tran L</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Fajardo+E%22">Fajardo E</searchLink>; Department of Computational and Systems Biology, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Fiser+A%22">Fiser A</searchLink>; Department of Computational and Systems Biology, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Karambizi+D%22">Karambizi D</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Tapinos+N%22">Tapinos N</searchLink>; Laboratory of Cancer Epigenetics and Plasticity, Brown University, Providence, Rhode Island, USA; Department of Neurosurgery, Brown University Health, Providence, Rhode Island, USA; Brown RNA Center, Brown University, Providence, Rhode Island, USA. Electronic address: nikos@homerbio.com.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110732. <i>Date of Electronic Publication: </i>2025 Sep 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2025.110732
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              Text: 2025 Oct
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