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Novel tetravalent bispecific antibody, PSMA/TRAIL‑R2 REGULGENT™, induces selective tumor cell apoptosis without hepatotoxicity.

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Title: Novel tetravalent bispecific antibody, PSMA/TRAIL‑R2 REGULGENT™, induces selective tumor cell apoptosis without hepatotoxicity.
Authors: Nakayama M; Core Research Laboratories, Bio‑Pharmaceutical Center, Research Division, Kyowa Kirin Co., Ltd., Tokyo 194‑8533, Japan., Takagi-Maeda S; Project and Product Management Group 3, CMC Development, Manufacturing, Kyowa Kirin Co., Ltd., Tokyo 100‑0004, Japan., Machino Y; Project and Product Management Group 3, CMC Development, Manufacturing, Kyowa Kirin Co., Ltd., Tokyo 100‑0004, Japan., Nihira K; Global Operational Transformation Kyowa Kirin International Plc., Marlow SL7 1HZ, UK., Inoue M; Innovation Center, Research Division, Kyowa Kirin Co., Ltd., Tokyo 194‑8533, Japan., Takahashi N; Innovation Center, Research Division, Kyowa Kirin Co., Ltd., Tokyo 194‑8533, Japan., Usami K; Innovation Center, Research Division, Kyowa Kirin Co., Ltd., Tokyo 194‑8533, Japan.
Source: Oncology reports [Oncol Rep] 2025 Nov; Vol. 54 (5). Date of Electronic Publication: 2025 Sep 19.
Publication Type: Journal Article
Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel tetravalent bispecific antibody, PSMA/TRAIL‑R2 REGULGENT™, induces selective tumor cell apoptosis without hepatotoxicity.
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  Data: <searchLink fieldCode="AU" term="%22Nakayama+M%22">Nakayama M</searchLink>; Core Research Laboratories, Bio‑Pharmaceutical Center, Research Division, Kyowa Kirin Co., Ltd., Tokyo 194‑8533, Japan.<br /><searchLink fieldCode="AU" term="%22Takagi-Maeda+S%22">Takagi-Maeda S</searchLink>; Project and Product Management Group 3, CMC Development, Manufacturing, Kyowa Kirin Co., Ltd., Tokyo 100‑0004, Japan.<br /><searchLink fieldCode="AU" term="%22Machino+Y%22">Machino Y</searchLink>; Project and Product Management Group 3, CMC Development, Manufacturing, Kyowa Kirin Co., Ltd., Tokyo 100‑0004, Japan.<br /><searchLink fieldCode="AU" term="%22Nihira+K%22">Nihira K</searchLink>; Global Operational Transformation Kyowa Kirin International Plc., Marlow SL7 1HZ, UK.<br /><searchLink fieldCode="AU" term="%22Inoue+M%22">Inoue M</searchLink>; Innovation Center, Research Division, Kyowa Kirin Co., Ltd., Tokyo 194‑8533, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+N%22">Takahashi N</searchLink>; Innovation Center, Research Division, Kyowa Kirin Co., Ltd., Tokyo 194‑8533, Japan.<br /><searchLink fieldCode="AU" term="%22Usami+K%22">Usami K</searchLink>; Innovation Center, Research Division, Kyowa Kirin Co., Ltd., Tokyo 194‑8533, Japan.
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  Data: <searchLink fieldCode="JN" term="%229422756%22">Oncology reports</searchLink> [Oncol Rep] 2025 Nov; Vol. 54 (5). <i>Date of Electronic Publication: </i>2025 Sep 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22D%2EA%2E+Spandidos%22">D.A. Spandidos </searchLink><i>Country of Publication: </i>Greece <i>NLM ID: </i>9422756 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1791-2431 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221021335X%22">1021335X </searchLink><i>NLM ISO Abbreviation: </i>Oncol Rep <i>Subsets: </i>MEDLINE
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        Value: 10.3892/or.2025.8988
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      – Code: eng
        Text: English
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      – TitleFull: Novel tetravalent bispecific antibody, PSMA/TRAIL‑R2 REGULGENT™, induces selective tumor cell apoptosis without hepatotoxicity.
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              Text: 2025 Nov
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              Y: 2025
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              Value: 1791-2431
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              Value: 54
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