Astragaloside IV delayed the epithelial-mesenchymal transition in peritoneal fibrosis by inhibiting the activation of EGFR and PI3K-AKT pathways.

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Title: Astragaloside IV delayed the epithelial-mesenchymal transition in peritoneal fibrosis by inhibiting the activation of EGFR and PI3K-AKT pathways.
Authors: Huang Y; School of Public Health, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China; Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China., Chu CL; Department of Clinical Medicine and Stomatology, Hangzhou Normal University, Hangzhou 310014, Zhejiang Province, China; Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China., Qiu WH; Basic Medical Sciences, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China; Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China., Chen JY; Department of Clinical Medicine and Stomatology, Hangzhou Normal University, Hangzhou 310014, Zhejiang Province, China; Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China., Cao LX; Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China., Ji SY; Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China., Zhu B; Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China., Wang GK; Department of Cardiovascular Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China. Electronic address: dearwgk@smmu.edu.cn., Shen QQ; Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China; Department of Nephrology, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie 551700, Guizhou Province, China. Electronic address: spring198457@sina.com.
Source: Journal of integrative medicine [J Integr Med] 2025 Nov; Vol. 23 (6), pp. 694-705. Date of Electronic Publication: 2025 Sep 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101603118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2095-4964 (Print) NLM ISO Abbreviation: J Integr Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2095-4964
DOI:10.1016/j.joim.2025.09.001