De novo design of potent inhibitors of clostridial family toxins.

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Title: De novo design of potent inhibitors of clostridial family toxins.
Authors: Ragotte RJ; Department of Biochemistry, University of Washington, Seattle, WA 98195.; Institute for Protein Design, University of Washington, Seattle, WA 98195., Liang H; Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada., Tam J; Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada., Miletic S; Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4., Berman JM; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Palou R; Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4., Weidle C; Department of Biochemistry, University of Washington, Seattle, WA 98195.; Institute for Protein Design, University of Washington, Seattle, WA 98195., Li Z; Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4., Glögl M; Department of Biochemistry, University of Washington, Seattle, WA 98195.; Institute for Protein Design, University of Washington, Seattle, WA 98195., Beilhartz GL; Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4., Carr KD; Department of Biochemistry, University of Washington, Seattle, WA 98195.; Institute for Protein Design, University of Washington, Seattle, WA 98195., Borst AJ; Department of Biochemistry, University of Washington, Seattle, WA 98195.; Institute for Protein Design, University of Washington, Seattle, WA 98195., Coventry B; Department of Biochemistry, University of Washington, Seattle, WA 98195.; Institute for Protein Design, University of Washington, Seattle, WA 98195.; HHMI, University of Washington, Seattle, WA 98195., Wang X; Department of Biochemistry, University of Washington, Seattle, WA 98195.; Institute for Protein Design, University of Washington, Seattle, WA 98195., Rubinstein JL; Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 1L7., Tyers M; Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8., Melnyk RA; Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada M5G 0A4.; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada., Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98195.; Institute for Protein Design, University of Washington, Seattle, WA 98195.; HHMI, University of Washington, Seattle, WA 98195.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Sep 30; Vol. 122 (39), pp. e2509329122. Date of Electronic Publication: 2025 Sep 22.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2509329122