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2-Aminothiophene derivatives reduce resistance to fluoroquinolones in Staphylococcus aureus strains which overexpress NorA and MepA efflux pumps.

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Title: 2-Aminothiophene derivatives reduce resistance to fluoroquinolones in Staphylococcus aureus strains which overexpress NorA and MepA efflux pumps.
Authors: de Sousa Fernandes PA; Department of Biological Science, Laboratory of Synthesis and Drug Delivery-LSVM, State University of Paraiba, 58071-160, João Pessoa, PB, Brazil; Department of Pharmaceutical Sciences. Graduate Program in Natural and Synthetic Bioactive Products. Federal University of Paraiba, 58015-970, João Pessoa, PB, Brazil., de Araújo RSA; Department of Biological Science, Laboratory of Synthesis and Drug Delivery-LSVM, State University of Paraiba, 58071-160, João Pessoa, PB, Brazil; Department of Pharmaceutical Sciences. Graduate Program in Natural and Synthetic Bioactive Products. Federal University of Paraiba, 58015-970, João Pessoa, PB, Brazil., Gonçalves Alencar G; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil., Gonçalves SA; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil., de Araújo GA; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil., de Sousa Rodrigues EY; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil., Alves DS; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil., de Almeida RS; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil., de Morais Oliveira-Tintino CD; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil., Sidrônio MGS; Health Sciences Center. Graduate Program in Development and Technological Innovation in Medicines, Federal University of Paraiba, 58015-970, João Pessoa, PB, Brazil., Rodrigues VS; Department of Pharmaceutical Sciences. Graduate Program in Natural and Synthetic Bioactive Products. Federal University of Paraiba, 58015-970, João Pessoa, PB, Brazil., Araújo Padilha EK; Research Group on Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, AC Simões campus, 57072-970, Maceió, Alagoas, Brazil., da Silva EF; Research Group on Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, AC Simões campus, 57072-970, Maceió, Alagoas, Brazil., Nayarisseri A; In Silico Research Laboratory, Eminent Biosciences, Mahalakshmi Nagar, Indore, 452010, India., da Silva TG; Departament of Antibiotics, Federal University of Pernambuco, 50670-910, Recife, PE, Brazil., de Melo Coutinho HD; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil., Mendonça-Junior FJB; Department of Biological Science, Laboratory of Synthesis and Drug Delivery-LSVM, State University of Paraiba, 58071-160, João Pessoa, PB, Brazil; Department of Pharmaceutical Sciences. Graduate Program in Natural and Synthetic Bioactive Products. Federal University of Paraiba, 58015-970, João Pessoa, PB, Brazil. Electronic address: franciscojaime@servidor.uepb.edu.br.
Source: Biochimie [Biochimie] 2025 Dec; Vol. 239 (Pt B), pp. 191-206. Date of Electronic Publication: 2025 Sep 20.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE
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  Data: 2-Aminothiophene derivatives reduce resistance to fluoroquinolones in Staphylococcus aureus strains which overexpress NorA and MepA efflux pumps.
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  Data: <searchLink fieldCode="AU" term="%22de+Sousa+Fernandes+PA%22">de Sousa Fernandes PA</searchLink>; Department of Biological Science, Laboratory of Synthesis and Drug Delivery-LSVM, State University of Paraiba, 58071-160, João Pessoa, PB, Brazil; Department of Pharmaceutical Sciences. Graduate Program in Natural and Synthetic Bioactive Products. Federal University of Paraiba, 58015-970, João Pessoa, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Araújo+RSA%22">de Araújo RSA</searchLink>; Department of Biological Science, Laboratory of Synthesis and Drug Delivery-LSVM, State University of Paraiba, 58071-160, João Pessoa, PB, Brazil; Department of Pharmaceutical Sciences. Graduate Program in Natural and Synthetic Bioactive Products. Federal University of Paraiba, 58015-970, João Pessoa, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+Alencar+G%22">Gonçalves Alencar G</searchLink>; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+SA%22">Gonçalves SA</searchLink>; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Araújo+GA%22">de Araújo GA</searchLink>; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+Rodrigues+EY%22">de Sousa Rodrigues EY</searchLink>; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+DS%22">Alves DS</searchLink>; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Almeida+RS%22">de Almeida RS</searchLink>; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Morais+Oliveira-Tintino+CD%22">de Morais Oliveira-Tintino CD</searchLink>; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22Sidrônio+MGS%22">Sidrônio MGS</searchLink>; Health Sciences Center. Graduate Program in Development and Technological Innovation in Medicines, Federal University of Paraiba, 58015-970, João Pessoa, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+VS%22">Rodrigues VS</searchLink>; Department of Pharmaceutical Sciences. Graduate Program in Natural and Synthetic Bioactive Products. Federal University of Paraiba, 58015-970, João Pessoa, PB, Brazil.<br /><searchLink fieldCode="AU" term="%22Araújo+Padilha+EK%22">Araújo Padilha EK</searchLink>; Research Group on Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, AC Simões campus, 57072-970, Maceió, Alagoas, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+EF%22">da Silva EF</searchLink>; Research Group on Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, AC Simões campus, 57072-970, Maceió, Alagoas, Brazil.<br /><searchLink fieldCode="AU" term="%22Nayarisseri+A%22">Nayarisseri A</searchLink>; In Silico Research Laboratory, Eminent Biosciences, Mahalakshmi Nagar, Indore, 452010, India.<br /><searchLink fieldCode="AU" term="%22da+Silva+TG%22">da Silva TG</searchLink>; Departament of Antibiotics, Federal University of Pernambuco, 50670-910, Recife, PE, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Melo+Coutinho+HD%22">de Melo Coutinho HD</searchLink>; Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, 63105-000, Crato, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22Mendonça-Junior+FJB%22">Mendonça-Junior FJB</searchLink>; Department of Biological Science, Laboratory of Synthesis and Drug Delivery-LSVM, State University of Paraiba, 58071-160, João Pessoa, PB, Brazil; Department of Pharmaceutical Sciences. Graduate Program in Natural and Synthetic Bioactive Products. Federal University of Paraiba, 58015-970, João Pessoa, PB, Brazil. Electronic address: franciscojaime@servidor.uepb.edu.br.
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  Data: <searchLink fieldCode="JN" term="%221264604%22">Biochimie</searchLink> [Biochimie] 2025 Dec; Vol. 239 (Pt B), pp. 191-206. <i>Date of Electronic Publication: </i>2025 Sep 20.
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        Text: English
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