UBE2O-mediated ubiquitylation directs cytoplasmic CTNNA1 to promote cell-to-ECM adhesions.

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Title: UBE2O-mediated ubiquitylation directs cytoplasmic CTNNA1 to promote cell-to-ECM adhesions.
Authors: Xiang D; Laboratory of Proteomics and Ubiquitin Signaling, Center for Cell Lineage Altas, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 510530, Guangzhou, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 510530, Guangzhou, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Wu W; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, the Fifth Affiliated Hospital of Guangzhou Medical University, 510799, Guangzhou, Guangdong, China., Shi R; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, 15 Science Park West Avenue, Hong Kong Science Park, Hong Kong SAR, China., Tang X; Laboratory of Proteomics and Ubiquitin Signaling, Center for Cell Lineage Altas, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 510530, Guangzhou, China.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 510530, Guangzhou, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhang X; Laboratory of Proteomics and Ubiquitin Signaling, Center for Cell Lineage Altas, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 510530, Guangzhou, China. zhang_xiaofei@gibh.ac.cn.; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 510530, Guangzhou, China. zhang_xiaofei@gibh.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. zhang_xiaofei@gibh.ac.cn.
Source: EMBO reports [EMBO Rep] 2025 Nov; Vol. 26 (22), pp. 5431-5458. Date of Electronic Publication: 2025 Sep 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1469-3178
DOI:10.1038/s44319-025-00585-4