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Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank.

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Title: Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank.
Authors: Xu W; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK., Mesa-Eguiagaray I; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK., Morris DM; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK.; Edinburgh Imaging, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK., Wang C; Edinburgh Imaging, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK.; School of Mathematics and Computer Sciences, Heriot-Watt University, Edinburgh, UK., Gray CD; Edinburgh Imaging, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK., Sjöström S; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK., Papanastasiou G; Edinburgh Imaging, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK.; Archimedes Unit, Athena Research Centre, Artemidos 1, Marousi, Greece., Badr S; Univ. Lille, CHU Lille, Marrow Adiposity and Bone Laboratory (MABlab) ULR 4490, Department of Rheumatology, Lille, France., Paccou J; Univ. Lille, CHU Lille, Marrow Adiposity and Bone Laboratory (MABlab) ULR 4490, Department of Rheumatology, Lille, France., Wang L; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK., Li X; Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Timmers PRHJ; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK., Timofeeva M; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Danish Institute for Advanced Study (DIAS), Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark., Semple SI; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK.; Edinburgh Imaging, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK., MacGillivray T; Centre for Clinical Brain Sciences, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK., Theodoratou E; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK. E.Theodoratou@ed.ac.uk.; Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. E.Theodoratou@ed.ac.uk., Cawthorn WP; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK. W.Cawthorn@ed.ac.uk.
Source: Nature communications [Nat Commun] 2025 Sep 23; Vol. 16 (1), pp. 8332. Date of Electronic Publication: 2025 Sep 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank.
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  Data: <searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink>; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Mesa-Eguiagaray+I%22">Mesa-Eguiagaray I</searchLink>; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Morris+DM%22">Morris DM</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK.; Edinburgh Imaging, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Edinburgh Imaging, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK.; School of Mathematics and Computer Sciences, Heriot-Watt University, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Gray+CD%22">Gray CD</searchLink>; Edinburgh Imaging, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Sjöström+S%22">Sjöström S</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Papanastasiou+G%22">Papanastasiou G</searchLink>; Edinburgh Imaging, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK.; Archimedes Unit, Athena Research Centre, Artemidos 1, Marousi, Greece.<br /><searchLink fieldCode="AU" term="%22Badr+S%22">Badr S</searchLink>; Univ. Lille, CHU Lille, Marrow Adiposity and Bone Laboratory (MABlab) ULR 4490, Department of Rheumatology, Lille, France.<br /><searchLink fieldCode="AU" term="%22Paccou+J%22">Paccou J</searchLink>; Univ. Lille, CHU Lille, Marrow Adiposity and Bone Laboratory (MABlab) ULR 4490, Department of Rheumatology, Lille, France.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Timmers+PRHJ%22">Timmers PRHJ</searchLink>; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Timofeeva+M%22">Timofeeva M</searchLink>; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Danish Institute for Advanced Study (DIAS), Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Semple+SI%22">Semple SI</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK.; Edinburgh Imaging, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22MacGillivray+T%22">MacGillivray T</searchLink>; Centre for Clinical Brain Sciences, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Theodoratou+E%22">Theodoratou E</searchLink>; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK. E.Theodoratou@ed.ac.uk.; Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. E.Theodoratou@ed.ac.uk.<br /><searchLink fieldCode="AU" term="%22Cawthorn+WP%22">Cawthorn WP</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK. W.Cawthorn@ed.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Sep 23; Vol. 16 (1), pp. 8332. <i>Date of Electronic Publication: </i>2025 Sep 23.
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