Impaired early type I interferon responses to influenza virus infection in aged mice are associated with subsequent increased pulmonary inflammation.

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Title: Impaired early type I interferon responses to influenza virus infection in aged mice are associated with subsequent increased pulmonary inflammation.
Authors: Wu W; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA. wenxin-wu@ouhsc.edu., Alexander JS; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA., Booth JL; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA., Huang C; The Lundberg-Kienlen Lung Diseases and Infection Laboratory, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA., Liu L; The Lundberg-Kienlen Lung Diseases and Infection Laboratory, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA., Miller CA; Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA., Drevets DA; Infectious Diseases, Department of Medicine, University of Oklahoma Health Sciences Center, 800 Stanton L. Young Blvd, Suite 7300, Oklahoma City, OK, 73104, USA. douglas-drevets@ouhsc.edu., Metcalf JP; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA. jordan-metcalf@ouhsc.edu.; Veterans Affairs Medical Center, Oklahoma City, OK, USA. jordan-metcalf@ouhsc.edu.; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. jordan-metcalf@ouhsc.edu.
Source: GeroScience [Geroscience] 2026 Jun; Vol. 48 (3), pp. 4225-4245. Date of Electronic Publication: 2025 Sep 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2509-2723
DOI:10.1007/s11357-025-01892-3