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Impaired early type I interferon responses to influenza virus infection in aged mice are associated with subsequent increased pulmonary inflammation.

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Title: Impaired early type I interferon responses to influenza virus infection in aged mice are associated with subsequent increased pulmonary inflammation.
Authors: Wu W; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA. wenxin-wu@ouhsc.edu., Alexander JS; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA., Booth JL; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA., Huang C; The Lundberg-Kienlen Lung Diseases and Infection Laboratory, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA., Liu L; The Lundberg-Kienlen Lung Diseases and Infection Laboratory, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA., Miller CA; Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA., Drevets DA; Infectious Diseases, Department of Medicine, University of Oklahoma Health Sciences Center, 800 Stanton L. Young Blvd, Suite 7300, Oklahoma City, OK, 73104, USA. douglas-drevets@ouhsc.edu., Metcalf JP; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA. jordan-metcalf@ouhsc.edu.; Veterans Affairs Medical Center, Oklahoma City, OK, USA. jordan-metcalf@ouhsc.edu.; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. jordan-metcalf@ouhsc.edu.
Source: GeroScience [Geroscience] 2026 Jun; Vol. 48 (3), pp. 4225-4245. Date of Electronic Publication: 2025 Sep 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impaired early type I interferon responses to influenza virus infection in aged mice are associated with subsequent increased pulmonary inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Wu+W%22">Wu W</searchLink>; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA. wenxin-wu@ouhsc.edu.<br /><searchLink fieldCode="AU" term="%22Alexander+JS%22">Alexander JS</searchLink>; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Booth+JL%22">Booth JL</searchLink>; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; The Lundberg-Kienlen Lung Diseases and Infection Laboratory, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; The Lundberg-Kienlen Lung Diseases and Infection Laboratory, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA.<br /><searchLink fieldCode="AU" term="%22Miller+CA%22">Miller CA</searchLink>; Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA.<br /><searchLink fieldCode="AU" term="%22Drevets+DA%22">Drevets DA</searchLink>; Infectious Diseases, Department of Medicine, University of Oklahoma Health Sciences Center, 800 Stanton L. Young Blvd, Suite 7300, Oklahoma City, OK, 73104, USA. douglas-drevets@ouhsc.edu.<br /><searchLink fieldCode="AU" term="%22Metcalf+JP%22">Metcalf JP</searchLink>; Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Room 425, 800 N. Research Pkwy, Oklahoma City, OK, 73104, USA. jordan-metcalf@ouhsc.edu.; Veterans Affairs Medical Center, Oklahoma City, OK, USA. jordan-metcalf@ouhsc.edu.; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. jordan-metcalf@ouhsc.edu.
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2026 Jun; Vol. 48 (3), pp. 4225-4245. <i>Date of Electronic Publication: </i>2025 Sep 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11357-025-01892-3
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      – Code: eng
        Text: English
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              Text: 2026 Jun
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              Y: 2026
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