Sex Differences in Prognosis of Patients With Genetic Dilated Cardiomyopathy.

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Title: Sex Differences in Prognosis of Patients With Genetic Dilated Cardiomyopathy.
Authors: Stroeks SLVM; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), the Netherlands (S.L.V.M.S., M.A.S., R.E.W.v.L., M.T.H.M.H., A.G.R., M.F.H., E.A.V.J., S.R.B.H., J.A.J.V.).; KU Leuven, Cardiovascular Sciences, Belgium (S.L.V.M.S., E.A.V.J., S.R.B.H.).; Department of Clinical Genetics, Maastricht University Medical Center, the Netherlands (S.L.V.M.S., P.W., D.M.E.I.H., I.P.C.K., A.v.d.W., M.F.H., M.N., H.G.B., J.A.J.V.).; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.)., Merlo M; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Cardiovascular Department, Azienda Sanitaria-Universitaria Integrata Trieste ASUITS, Italy (M.M., A.C., M.D.F., M.S., C.P.L.D.G., M.I., G.S.)., Mora-Ayestaran N; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV, Madrid, Spain (N.M.-A., B.P., E.G.-L., F.D., P.G.-P.)., Jason M; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado Anschutz Medical Campus, Aurora (M.J., M.T., L.M.)., Tayal U; National Heart and Lung Institute, Imperial College London, United Kingdom (U.T.).; Royal Brompton and Harefield Clinical Group, Guy's and St Thomas' NHS Foundation Trust, United Kingdom (U.T.)., Wang P; Department of Clinical Genetics, Maastricht University Medical Center, the Netherlands (S.L.V.M.S., P.W., D.M.E.I.H., I.P.C.K., A.v.d.W., M.F.H., M.N., H.G.B., J.A.J.V.).; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.)., Cannatà A; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Cardiovascular Department, Azienda Sanitaria-Universitaria Integrata Trieste ASUITS, Italy (M.M., A.C., M.D.F., M.S., C.P.L.D.G., M.I., G.S.).; School of Cardiovascular Medicine and Metabolic Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, King's College London, United Kingdom (A.C.).; Department of Cardiology, King's College Hospital London, United Kingdom (A.C.)., Sikking MA; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), the Netherlands (S.L.V.M.S., M.A.S., R.E.W.v.L., M.T.H.M.H., A.G.R., M.F.H., E.A.V.J., S.R.B.H., J.A.J.V.).; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.)., Dal Ferro M; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Cardiovascular Department, Azienda Sanitaria-Universitaria Integrata Trieste ASUITS, Italy (M.M., A.C., M.D.F., M.S., C.P.L.D.G., M.I., G.S.)., Peiro B; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV, Madrid, Spain (N.M.-A., B.P., E.G.-L., F.D., P.G.-P.)., Willemars M; Department of Genetics and Cell Biology, Maastricht University, the Netherlands (M.W., M.N.)., Hellebrekers DMEI; Department of Clinical Genetics, Maastricht University Medical Center, the Netherlands (S.L.V.M.S., P.W., D.M.E.I.H., I.P.C.K., A.v.d.W., M.F.H., M.N., H.G.B., J.A.J.V.).; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.)., van Leeuwen REW; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), the Netherlands (S.L.V.M.S., M.A.S., R.E.W.v.L., M.T.H.M.H., A.G.R., M.F.H., E.A.V.J., S.R.B.H., J.A.J.V.)., Setti M; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Cardiovascular Department, Azienda Sanitaria-Universitaria Integrata Trieste ASUITS, Italy (M.M., A.C., M.D.F., M.S., C.P.L.D.G., M.I., G.S.).; University of Verona, Section of Cardiology, Italy (M.S., J.P.O.)., Gonzalez-Lopez E; Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV, Madrid, Spain (N.M.-A., B.P., E.G.-L., F.D., P.G.-P.)., Krapels IPC; Department of Clinical Genetics, Maastricht University Medical Center, the Netherlands (S.L.V.M.S., P.W., D.M.E.I.H., I.P.C.K., A.v.d.W., M.F.H., M.N., H.G.B., J.A.J.V.).; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.)., Pio Loco Detto Gava C; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Cardiovascular Department, Azienda Sanitaria-Universitaria Integrata Trieste ASUITS, Italy (M.M., A.C., M.D.F., M.S., C.P.L.D.G., M.I., G.S.)., van den Wijngaard A; Department of Clinical Genetics, Maastricht University Medical Center, the Netherlands (S.L.V.M.S., P.W., D.M.E.I.H., I.P.C.K., A.v.d.W., M.F.H., M.N., H.G.B., J.A.J.V.).; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.)., Henkens MTHM; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), the Netherlands (S.L.V.M.S., M.A.S., R.E.W.v.L., M.T.H.M.H., A.G.R., M.F.H., E.A.V.J., S.R.B.H., J.A.J.V.).; Department of Pathology, Maastricht University Medical Centre, the Netherlands (M.T.H.M.H.).; Netherlands Heart Institute (NLHI), Utrecht, the Netherlands (M.T.H.M.H.)., Iseppi M; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Cardiovascular Department, Azienda Sanitaria-Universitaria Integrata Trieste ASUITS, Italy (M.M., A.C., M.D.F., M.S., C.P.L.D.G., M.I., G.S.)., Raafs AG; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), the Netherlands (S.L.V.M.S., M.A.S., R.E.W.v.L., M.T.H.M.H., A.G.R., M.F.H., E.A.V.J., S.R.B.H., J.A.J.V.)., Hoes MF; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), the Netherlands (S.L.V.M.S., M.A.S., R.E.W.v.L., M.T.H.M.H., A.G.R., M.F.H., E.A.V.J., S.R.B.H., J.A.J.V.).; Department of Clinical Genetics, Maastricht University Medical Center, the Netherlands (S.L.V.M.S., P.W., D.M.E.I.H., I.P.C.K., A.v.d.W., M.F.H., M.N., H.G.B., J.A.J.V.)., van Empel VPM; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Department of Cardiology, University of Maastricht, Medical University Center Maastricht, the Netherlands (V.P.M.v.E.)., Jones EAV; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), the Netherlands (S.L.V.M.S., M.A.S., R.E.W.v.L., M.T.H.M.H., A.G.R., M.F.H., E.A.V.J., S.R.B.H., J.A.J.V.).; KU Leuven, Cardiovascular Sciences, Belgium (S.L.V.M.S., E.A.V.J., S.R.B.H.)., Nabben M; Department of Clinical Genetics, Maastricht University Medical Center, the Netherlands (S.L.V.M.S., P.W., D.M.E.I.H., I.P.C.K., A.v.d.W., M.F.H., M.N., H.G.B., J.A.J.V.).; Department of Genetics and Cell Biology, Maastricht University, the Netherlands (M.W., M.N.)., Taylor M; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado Anschutz Medical Campus, Aurora (M.J., M.T., L.M.)., Brunner HG; Department of Clinical Genetics, Maastricht University Medical Center, the Netherlands (S.L.V.M.S., P.W., D.M.E.I.H., I.P.C.K., A.v.d.W., M.F.H., M.N., H.G.B., J.A.J.V.).; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Radboud University Medical Center, Human Genetics, Nijmegen, the Netherlands (H.G.B.)., Ochoa JP; University of Verona, Section of Cardiology, Italy (M.S., J.P.O.).; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (J.P.O., F.D., P.G.-P.)., Dominguez F; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV, Madrid, Spain (N.M.-A., B.P., E.G.-L., F.D., P.G.-P.).; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (J.P.O., F.D., P.G.-P.)., Lakdawala NK; Brigham and Women's Hospital, Division of Cardiovascular Medicine, Harvard Medical School, Boston, MA (N.K.L.)., Sinagra G; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Cardiovascular Department, Azienda Sanitaria-Universitaria Integrata Trieste ASUITS, Italy (M.M., A.C., M.D.F., M.S., C.P.L.D.G., M.I., G.S.)., Garcia-Pavia P; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).; Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro, IDIPHISA, CIBERCV, Madrid, Spain (N.M.-A., B.P., E.G.-L., F.D., P.G.-P.).; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (J.P.O., F.D., P.G.-P.)., Mestroni L; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado Anschutz Medical Campus, Aurora (M.J., M.T., L.M.)., Heymans SRB; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), the Netherlands (S.L.V.M.S., M.A.S., R.E.W.v.L., M.T.H.M.H., A.G.R., M.F.H., E.A.V.J., S.R.B.H., J.A.J.V.).; KU Leuven, Cardiovascular Sciences, Belgium (S.L.V.M.S., E.A.V.J., S.R.B.H.)., Verdonschot JAJ; Department of Cardiology, Maastricht University, Cardiovascular Research Institute Maastricht (CARIM), the Netherlands (S.L.V.M.S., M.A.S., R.E.W.v.L., M.T.H.M.H., A.G.R., M.F.H., E.A.V.J., S.R.B.H., J.A.J.V.).; Department of Clinical Genetics, Maastricht University Medical Center, the Netherlands (S.L.V.M.S., P.W., D.M.E.I.H., I.P.C.K., A.v.d.W., M.F.H., M.N., H.G.B., J.A.J.V.).; Members of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (S.L.V.M.S., M.M., N.M.-A., P.W., A.C., M.A.S., M.D.F., B.P., D.M.E.I.H., M.S., I.P.C.K., C.P.L.D.G., A.v.d.W., M.I., V.P.M.v.E., H.G.B., F.D., G.S., P.G.-P., J.A.J.V.).
Source: Circulation. Heart failure [Circ Heart Fail] 2025 Nov; Vol. 18 (11), pp. e012592. Date of Electronic Publication: 2025 Sep 24.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101479941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-3297 (Electronic) Linking ISSN: 19413289 NLM ISO Abbreviation: Circ Heart Fail Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1941-3297
DOI:10.1161/CIRCHEARTFAILURE.124.012592