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Ascorbic Acid Modulates Collagen Properties in Glucocorticoid-Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation.

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Title: Ascorbic Acid Modulates Collagen Properties in Glucocorticoid-Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation.
Authors: Curtis M; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Kim Y; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Patil R; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Zhang X; Institute for Soft Matter Synthesis and Metrology, Georgetown University, Washington DC, 20057, United States.; Department of Physics, Georgetown University, Washington DC, 20057, United States., Jayatilake M; Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, 20057, United States., Bulgin O; Department of Physics, Georgetown University, Washington DC, 20057, United States., Lialios P; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Surrency S; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Tarrah S; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Lazaris AK; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Grafton A; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Williams J 4th; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States., Nouraie SB; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Bizaki M; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Xeron P; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Van Keuren E; Department of Physics, Georgetown University, Washington DC, 20057, United States., Seppala JE; Materials Science and Engineering Division, Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg MD, 20899, United States., Laiakis EC; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, 20057, United States.; Department of Radiation, Georgetown University, Washington DC, 20057, United States.; Center for Metabolomic Studies, Georgetown University, Washington DC, 20057, United States., Kitlinska JB; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States., Alimperti S; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States.; Institute for Soft Matter Synthesis and Metrology, Georgetown University, Washington DC, 20057, United States.
Source: Advanced healthcare materials [Adv Healthc Mater] 2026 Mar; Vol. 15 (12), pp. e02606. Date of Electronic Publication: 2025 Sep 25.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
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  Data: Ascorbic Acid Modulates Collagen Properties in Glucocorticoid-Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation.
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Department of Physics, Georgetown University, Washington DC, 20057, United States.<br /><searchLink fieldCode="AU" term="%22Jayatilake+M%22">Jayatilake M</searchLink>; Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, 20057, United States.<br /><searchLink fieldCode="AU" term="%22Bulgin+O%22">Bulgin O</searchLink>; Department of Physics, Georgetown University, Washington DC, 20057, United States.<br /><searchLink fieldCode="AU" term="%22Lialios+P%22">Lialios P</searchLink>; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States.<br /><searchLink fieldCode="AU" term="%22Surrency+S%22">Surrency S</searchLink>; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States.<br /><searchLink fieldCode="AU" term="%22Tarrah+S%22">Tarrah S</searchLink>; 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Materials Science and Engineering Division, Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg MD, 20899, United States.<br /><searchLink fieldCode="AU" term="%22Laiakis+EC%22">Laiakis EC</searchLink>; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, 20057, United States.; Department of Radiation, Georgetown University, Washington DC, 20057, United States.; Center for Metabolomic Studies, Georgetown University, Washington DC, 20057, United States.<br /><searchLink fieldCode="AU" term="%22Kitlinska+JB%22">Kitlinska JB</searchLink>; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States.<br /><searchLink fieldCode="AU" term="%22Alimperti+S%22">Alimperti S</searchLink>; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, 20057, United States.; Center for Biological and Biomedical Engineering, Georgetown University, Washington DC, 20057, United States.; Institute for Soft Matter Synthesis and Metrology, Georgetown University, Washington DC, 20057, United States.
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