Blood Biomarker and Raman Analysis of Leukocytes in the Multicenter Intelligence Trials: At the Intensive Care Unit (Intelligence-1) and the Emergency Department (Intelligence-2).

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Title: Blood Biomarker and Raman Analysis of Leukocytes in the Multicenter Intelligence Trials: At the Intensive Care Unit (Intelligence-1) and the Emergency Department (Intelligence-2).
Authors: Giamarellos-Bourboulis EJ; Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Thomas-Rüddel D; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.; Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York., Pistiki A; Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Ramoji A; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany., Ryabchykov O; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany., Azam KSF; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany., Toutouzas K; First Department of Propedeutic Surgery, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Prekates A; Intensive Care Unit, Tzaneion General Hospital, Piraeus, Greece., Karatzas S; Intensive Care Unit, Ippokration General Hospital, Athens, Greece., Mathas C; Intensive Care Unit, Aghia Olga Konstantopouleion General Hospital, Athens, Greece., Kotsaki A; Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Chalvatzis S; Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Antonakos N; Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Damoraki G; Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Rüger J; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany., Knorr F; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany., Arend N; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany., Silge A; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany., Schie I; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany., Eugen-Olsen J; Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Copenhagen, Denmark.; Department of Clinical Research, Copenhagen University Hospital Hvidovre and Amager, Copenhagen, Denmark., Bocklitz T; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany., Bauer M; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Winning J; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Kiehntopf M; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Institute for Clinical Chemistry and Laboratory Diagnostics, Jena University Hospital, Jena, Germany., Popp J; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany., Bloos F; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Neugebauer U; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany.
Source: Shock (Augusta, Ga.) [Shock] 2026 Jan 01; Vol. 65 (1), pp. 15-21. Date of Electronic Publication: 2025 Sep 25.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9421564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-0514 (Electronic) Linking ISSN: 10732322 NLM ISO Abbreviation: Shock Subsets: MEDLINE
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  Data: Blood Biomarker and Raman Analysis of Leukocytes in the Multicenter Intelligence Trials: At the Intensive Care Unit (Intelligence-1) and the Emergency Department (Intelligence-2).
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  Data: <searchLink fieldCode="AU" term="%22Giamarellos-Bourboulis+EJ%22">Giamarellos-Bourboulis EJ</searchLink>; Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Thomas-Rüddel+D%22">Thomas-Rüddel D</searchLink>; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.; Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.<br /><searchLink fieldCode="AU" term="%22Pistiki+A%22">Pistiki A</searchLink>; Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Ramoji+A%22">Ramoji A</searchLink>; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Ryabchykov+O%22">Ryabchykov O</searchLink>; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Azam+KSF%22">Azam KSF</searchLink>; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Toutouzas+K%22">Toutouzas K</searchLink>; First Department of Propedeutic Surgery, National and Kapodistrian University of Athens, Medical School, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Prekates+A%22">Prekates A</searchLink>; 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Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Rüger+J%22">Rüger J</searchLink>; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Knorr+F%22">Knorr F</searchLink>; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Arend+N%22">Arend N</searchLink>; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Silge+A%22">Silge A</searchLink>; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Schie+I%22">Schie I</searchLink>; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Eugen-Olsen+J%22">Eugen-Olsen J</searchLink>; Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Copenhagen, Denmark.; Department of Clinical Research, Copenhagen University Hospital Hvidovre and Amager, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bocklitz+T%22">Bocklitz T</searchLink>; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Bauer+M%22">Bauer M</searchLink>; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Winning+J%22">Winning J</searchLink>; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Kiehntopf+M%22">Kiehntopf M</searchLink>; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.; Institute for Clinical Chemistry and Laboratory Diagnostics, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Popp+J%22">Popp J</searchLink>; Institute for Physical Chemistry, Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.; Leibniz Institute of Photonic Technology (Leibniz-IPHT), Member of Leibniz Research Alliance 'Health Technologies,' and member of the Leibniz Centre for Photonics in Infection Research (LPI), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Bloos+F%22">Bloos F</searchLink>; 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