Integrative structural profiling and ligand optimisation across the transthyretin mutational landscape.

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Title: Integrative structural profiling and ligand optimisation across the transthyretin mutational landscape.
Authors: Lomoio U; Department of Surgical and Medical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Carbonari V; Department of Surgical and Medical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Giorgi FM; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Ortuso F; Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Lió P; Department of Computer Science and Technology, Cambridge University, Cambridge, United Kingdom., Veltri P; DIMES, University of Calabria, Rende, Italy. pierangelo.veltri@dimes.unical.it., Guzzi PH; Department of Surgical and Medical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Source: NPJ systems biology and applications [NPJ Syst Biol Appl] 2025 Sep 25; Vol. 11 (1), pp. 104. Date of Electronic Publication: 2025 Sep 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group in partnership with SBI, The Systems Biology Institute Country of Publication: England NLM ID: 101677786 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-7189 (Electronic) Linking ISSN: 20567189 NLM ISO Abbreviation: NPJ Syst Biol Appl Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2056-7189
DOI:10.1038/s41540-025-00582-2