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Cryo-EM structures reveal the molecular mechanism of SUMO E1-E2 thioester transfer.

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Title: Cryo-EM structures reveal the molecular mechanism of SUMO E1-E2 thioester transfer.
Authors: Nayak A; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Nayak D; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Jia L; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Ruben EA; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Viswanadhapalli S; Department of Obstetrics and Gynecology, University of Texas Health, San Antonio, TX, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA., Dos Santos Bury P; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Nassar KM; Department of Obstetrics and Gynecology, University of Texas Health, San Antonio, TX, USA., Yu CH; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Tumanova AA; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Stratton CM; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Ebadi P; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Ivanov DN; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Sung P; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA., Vadlamudi RK; Department of Obstetrics and Gynecology, University of Texas Health, San Antonio, TX, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA.; Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, TX, USA., Wasmuth EV; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA., Olsen SK; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. olsens@uthscsa.edu.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA. olsens@uthscsa.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Dec; Vol. 32 (12), pp. 2441-2453. Date of Electronic Publication: 2025 Sep 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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