Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness.

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Title: Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness.
Authors: Kleyman A; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK., Pisciotta W; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK.; Department of Anaesthesia and Intensive Care, IRCCS-ISMETT (Istituto Mediterraneo per Trapianti e Terapie ad alta specializzazione), Palermo, Italy., Gaupp C; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK.; Department of Internal Medicine, Spital Limmattal, Schlieren, CH-8952, Switzerland., Khaliq W; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK., Hofmaenner D; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK.; Institute of Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland., Brealey D; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK.; Dept of Critical Care, University College London Hospitals NHS Foundation Trust, London, UK., Pinto BB; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK.; Division of Anaesthesiology, Geneva University Hospitals, Geneva, Switzerland., Andreis DT; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK.; S.C. Anaesthesia and Intensive Care, Legnano Hospital, ASST Ovest Milanese, Milan, Italy., Waugh MG; Division of Medicine, University College London, London, UK., Melis MJ; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK., Miller M; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK., Mehmetaj K; Dept of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Bauer M; Dept of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Press A; Dept of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany., Singer M; Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK. m.singer@ucl.ac.uk.
Source: Critical care (London, England) [Crit Care] 2025 Sep 25; Vol. 29 (1), pp. 399. Date of Electronic Publication: 2025 Sep 25.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1466-609X
DOI:10.1186/s13054-025-05638-7