A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease.

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Title: A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease.
Authors: Miller SJ; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Zhong H; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Wu W; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Cordova AM; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Smith ME; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Yashchenko A; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Li Z; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294 USA., Jafree DJ; Developmental Biology & Cancer Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, UCL, London, UK.; UCL Centre for Kidney and Bladder Health, University College London, London, UK.; Cellular Genetics Programme, Wellcome Trust Sanger Institute, Hinxton, UK., Zimmerman CN; Department of Pediatrics, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA., DeVette CI; Department of Pediatrics, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA., Do V; Division of Nephrology, Boston Children's Hospital, Boston, MA, United States., Hignite M; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Darby IG; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Ahmed KB; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Park Y; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Nusrat F; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Maryam B; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Lu S; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA., Li X; Department of Internal Medicine, Mayo Clinic, Rochester MN 55905, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA., Gipson JR; College of Medicine Core Facilities, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Li X; Department of Internal Medicine, Mayo Clinic, Rochester MN 55905, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA., Long DA; Developmental Biology & Cancer Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, UCL, London, UK.; UCL Centre for Kidney and Bladder Health, University College London, London, UK., Weiser-Evans M; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA., Yoder BK; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294 USA., Cowley BD Jr; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Hopp K; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA., Stubbs J; The Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA.; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA., Ma Q; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Ma A; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Zimmerman KA; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 20. Date of Electronic Publication: 2025 Sep 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.09.17.676846