A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease.

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Title: A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease.
Authors: Miller SJ; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Zhong H; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Wu W; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Cordova AM; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Smith ME; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Yashchenko A; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Li Z; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294 USA., Jafree DJ; Developmental Biology & Cancer Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, UCL, London, UK.; UCL Centre for Kidney and Bladder Health, University College London, London, UK.; Cellular Genetics Programme, Wellcome Trust Sanger Institute, Hinxton, UK., Zimmerman CN; Department of Pediatrics, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA., DeVette CI; Department of Pediatrics, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA., Do V; Division of Nephrology, Boston Children's Hospital, Boston, MA, United States., Hignite M; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Darby IG; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Ahmed KB; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Park Y; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Nusrat F; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Maryam B; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Lu S; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA., Li X; Department of Internal Medicine, Mayo Clinic, Rochester MN 55905, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA., Gipson JR; College of Medicine Core Facilities, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Li X; Department of Internal Medicine, Mayo Clinic, Rochester MN 55905, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA., Long DA; Developmental Biology & Cancer Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, UCL, London, UK.; UCL Centre for Kidney and Bladder Health, University College London, London, UK., Weiser-Evans M; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA., Yoder BK; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294 USA., Cowley BD Jr; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA., Hopp K; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA., Stubbs J; The Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA.; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA., Ma Q; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Ma A; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA., Zimmerman KA; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 20. Date of Electronic Publication: 2025 Sep 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease.
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  Data: <searchLink fieldCode="AU" term="%22Miller+SJ%22">Miller SJ</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+H%22">Zhong H</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Wu+W%22">Wu W</searchLink>; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Cordova+AM%22">Cordova AM</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Smith+ME%22">Smith ME</searchLink>; 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Department of Pediatrics, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22DeVette+CI%22">DeVette CI</searchLink>; Department of Pediatrics, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Do+V%22">Do V</searchLink>; Division of Nephrology, Boston Children's Hospital, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Hignite+M%22">Hignite M</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Darby+IG%22">Darby IG</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Ahmed+KB%22">Ahmed KB</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Park+Y%22">Park Y</searchLink>; 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College of Medicine Core Facilities, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Internal Medicine, Mayo Clinic, Rochester MN 55905, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Long+DA%22">Long DA</searchLink>; Developmental Biology & Cancer Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, UCL, London, UK.; UCL Centre for Kidney and Bladder Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Weiser-Evans+M%22">Weiser-Evans M</searchLink>; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.<br /><searchLink fieldCode="AU" term="%22Yoder+BK%22">Yoder BK</searchLink>; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294 USA.<br /><searchLink fieldCode="AU" term="%22Cowley+BD+Jr%22">Cowley BD Jr</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.<br /><searchLink fieldCode="AU" term="%22Hopp+K%22">Hopp K</searchLink>; Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.<br /><searchLink fieldCode="AU" term="%22Stubbs+J%22">Stubbs J</searchLink>; The Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA.; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA.<br /><searchLink fieldCode="AU" term="%22Ma+Q%22">Ma Q</searchLink>; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Ma+A%22">Ma A</searchLink>; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.; Pelotonia Institute for Immuno-Oncology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Zimmerman+KA%22">Zimmerman KA</searchLink>; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
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