Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors.

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Bibliographic Details
Title: Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors.
Authors: Bunney TD; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK., Nyvall HG; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada., Macrae C; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK., Lalović D; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK., Gregory A; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK., Le Huray KIP; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Harvey N; UCL School of Pharmacy, Brunswick Square, London, WC1E 6BT, UK., Pinotsis N; Institute of Structural and Molecular Biology, Birkbeck College, London, WC1E 6BT, UK., Kalli AC; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Waudby CA; UCL School of Pharmacy, Brunswick Square, London, WC1E 6BT, UK., Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.; Department of Biochemistry and Microbiology, University of British Columbia, Vancouver, BC, Canada.; University of Victoria, Genome BC Proteomics Centre, Victoria, BC, Canada., Katan M; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK.
Source: The Biochemical journal [Biochem J] 2025 Oct 16; Vol. 482 (20). Date of Electronic Publication: 2025 Oct 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Electronic Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1470-8728
DOI:10.1042/BCJ20253358