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Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors.

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Title: Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors.
Authors: Bunney TD; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK., Nyvall HG; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada., Macrae C; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK., Lalović D; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK., Gregory A; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK., Le Huray KIP; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Harvey N; UCL School of Pharmacy, Brunswick Square, London, WC1E 6BT, UK., Pinotsis N; Institute of Structural and Molecular Biology, Birkbeck College, London, WC1E 6BT, UK., Kalli AC; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK., Waudby CA; UCL School of Pharmacy, Brunswick Square, London, WC1E 6BT, UK., Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.; Department of Biochemistry and Microbiology, University of British Columbia, Vancouver, BC, Canada.; University of Victoria, Genome BC Proteomics Centre, Victoria, BC, Canada., Katan M; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK.
Source: The Biochemical journal [Biochem J] 2025 Oct 16; Vol. 482 (20). Date of Electronic Publication: 2025 Oct 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Electronic Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Bunney+TD%22">Bunney TD</searchLink>; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Nyvall+HG%22">Nyvall HG</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Macrae+C%22">Macrae C</searchLink>; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Lalović+D%22">Lalović D</searchLink>; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Gregory+A%22">Gregory A</searchLink>; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Le+Huray+KIP%22">Le Huray KIP</searchLink>; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.<br /><searchLink fieldCode="AU" term="%22Harvey+N%22">Harvey N</searchLink>; UCL School of Pharmacy, Brunswick Square, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Pinotsis+N%22">Pinotsis N</searchLink>; Institute of Structural and Molecular Biology, Birkbeck College, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Kalli+AC%22">Kalli AC</searchLink>; Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.<br /><searchLink fieldCode="AU" term="%22Waudby+CA%22">Waudby CA</searchLink>; UCL School of Pharmacy, Brunswick Square, London, WC1E 6BT, UK.<br /><searchLink fieldCode="AU" term="%22Burke+JE%22">Burke JE</searchLink>; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.; Department of Biochemistry and Microbiology, University of British Columbia, Vancouver, BC, Canada.; University of Victoria, Genome BC Proteomics Centre, Victoria, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Katan+M%22">Katan M</searchLink>; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, WC1E 6BT, UK.
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  Data: <searchLink fieldCode="JN" term="%222984726R%22">The Biochemical journal</searchLink> [Biochem J] 2025 Oct 16; Vol. 482 (20). <i>Date of Electronic Publication: </i>2025 Oct 16.
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