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I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression.

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Title: I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression.
Authors: Ho QWC; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Miller JA; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Gunaseelan D; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Chelliah R; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Babu HJ; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.; Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India., Chew XY; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Devaraj S; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Tay VS; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.; Nucleic Acid Therapeutics Initiative (NATi), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Kong D; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Biochemistry; Department of Medicine; Precision Medicine Translational Research Programme (TRP); Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore., Wang X; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Tan DY; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Rutter GA; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.; Centre de Recherche du CHUM, Faculté de Médicine, Université de Montréal, Montréal, QC, Canada.; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Research Institute of the McGill University Health Centre, Montréal, QC, Canada., Lee B; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Biochemistry; Department of Medicine; Precision Medicine Translational Research Programme (TRP); Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore., Ali Y; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore. Yusuf.ali@ntu.edu.sg.; Clinical Research Unit, Khoo Teck Puat Hospital, National Healthcare Group, Singapore, Republic of Singapore. Yusuf.ali@ntu.edu.sg.
Source: Diabetologia [Diabetologia] 2025 Dec; Vol. 68 (12), pp. 2767-2780. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
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  Data: I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression.
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  Data: <searchLink fieldCode="AU" term="%22Ho+QWC%22">Ho QWC</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Miller+JA%22">Miller JA</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Gunaseelan+D%22">Gunaseelan D</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Chelliah+R%22">Chelliah R</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Babu+HJ%22">Babu HJ</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.; Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Chew+XY%22">Chew XY</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Devaraj+S%22">Devaraj S</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+VS%22">Tay VS</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.; Nucleic Acid Therapeutics Initiative (NATi), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Kong+D%22">Kong D</searchLink>; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Biochemistry; Department of Medicine; Precision Medicine Translational Research Programme (TRP); Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+DY%22">Tan DY</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Rutter+GA%22">Rutter GA</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.; Centre de Recherche du CHUM, Faculté de Médicine, Université de Montréal, Montréal, QC, Canada.; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Research Institute of the McGill University Health Centre, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+B%22">Lee B</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Teo+AKK%22">Teo AKK</searchLink>; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Biochemistry; Department of Medicine; Precision Medicine Translational Research Programme (TRP); Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Ali+Y%22">Ali Y</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore. Yusuf.ali@ntu.edu.sg.; Clinical Research Unit, Khoo Teck Puat Hospital, National Healthcare Group, Singapore, Republic of Singapore. Yusuf.ali@ntu.edu.sg.
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              Text: 2025 Dec
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