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Population pharmacokinetics of ritonavir as a booster of lopinavir, atazanavir, or darunavir in African children with HIV.

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Title: Population pharmacokinetics of ritonavir as a booster of lopinavir, atazanavir, or darunavir in African children with HIV.
Authors: Tsirizani L; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.; Training and Research Unit of Excellence, Kamuzu University of Health Sciences, Blantyre, Malawi., Waalewijn H; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Szubert A; Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom., Mulenga V; Department of Paediatrics and Child Health, University of Zambia, School of Medicine, Lusaka, Zambia., Chabala C; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.; Department of Paediatrics and Child Health, University of Zambia, School of Medicine, Lusaka, Zambia.; University Teaching Hospital, Lusaka, Zambia., Bwakura-Dangarembizi M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.; University of Zimbabwe Faculty of Medicine and Health Sciences, Department of Child, Adolescent and Women's Health, Harare, Zimbabwe., Chitsamatanga M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Rutebarika DA; Department of Paediatrics, joint Clinical Research Centre, Kampala, Uganda., Musiime V; Department of Paediatrics, joint Clinical Research Centre, Kampala, Uganda.; Department of Paediatrics and Child Health, Makerere University, College of Health Sciences, School of Medicine, Kampala, Uganda., Kasozi M; Department of HIV Research, joint Clinical Research Centre, Mbarara, Uganda., Lugemwa A; Department of HIV Research, joint Clinical Research Centre, Mbarara, Uganda., McIlleron HM; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Burger DM; Department of Pharmacy, Radboudumc Research Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, the Netherlands., Gibb DM; Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom., Colbers A; Department of Pharmacy, Radboudumc Research Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, the Netherlands., Denti P; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa., Wasmann RE; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Corporate Authors: CHAPAS-4 trial team
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2025 Nov 05; Vol. 69 (11), pp. e0077125. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
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  Data: Population pharmacokinetics of ritonavir as a booster of lopinavir, atazanavir, or darunavir in African children with HIV.
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  Data: <searchLink fieldCode="AU" term="%22Tsirizani+L%22">Tsirizani L</searchLink>; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.; Training and Research Unit of Excellence, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Waalewijn+H%22">Waalewijn H</searchLink>; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Szubert+A%22">Szubert A</searchLink>; Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mulenga+V%22">Mulenga V</searchLink>; Department of Paediatrics and Child Health, University of Zambia, School of Medicine, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Chabala+C%22">Chabala C</searchLink>; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.; Department of Paediatrics and Child Health, University of Zambia, School of Medicine, Lusaka, Zambia.; University Teaching Hospital, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Bwakura-Dangarembizi+M%22">Bwakura-Dangarembizi M</searchLink>; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.; University of Zimbabwe Faculty of Medicine and Health Sciences, Department of Child, Adolescent and Women's Health, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Chitsamatanga+M%22">Chitsamatanga M</searchLink>; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Rutebarika+DA%22">Rutebarika DA</searchLink>; Department of Paediatrics, joint Clinical Research Centre, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Musiime+V%22">Musiime V</searchLink>; Department of Paediatrics, joint Clinical Research Centre, Kampala, Uganda.; Department of Paediatrics and Child Health, Makerere University, College of Health Sciences, School of Medicine, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Kasozi+M%22">Kasozi M</searchLink>; Department of HIV Research, joint Clinical Research Centre, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Lugemwa+A%22">Lugemwa A</searchLink>; Department of HIV Research, joint Clinical Research Centre, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22McIlleron+HM%22">McIlleron HM</searchLink>; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Burger+DM%22">Burger DM</searchLink>; Department of Pharmacy, Radboudumc Research Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gibb+DM%22">Gibb DM</searchLink>; Medical Research Council Clinical Trials Unit at University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Colbers+A%22">Colbers A</searchLink>; Department of Pharmacy, Radboudumc Research Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Denti+P%22">Denti P</searchLink>; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Wasmann+RE%22">Wasmann RE</searchLink>; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
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