Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats.

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Title: Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats.
Authors: Song R; Department of Infectious Disease, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China., Lin Y; School of Medicine, Southern University of Science and Technology, Shenzhen, China., Zhang M; Department of Ophthalmology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China., Liu Z; Department of Infectious Disease, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China., Zhang R; Department of Infectious Disease, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China., Zhao J; Department of Ophthalmology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China., Li B; Department of Infectious Disease, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China. libin@mail.sustech.edu.cn.; School of Medicine, Southern University of Science and Technology, Shenzhen, China. libin@mail.sustech.edu.cn.
Source: Nature communications [Nat Commun] 2025 Sep 26; Vol. 16 (1), pp. 8522. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-63553-5