Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.

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Title: Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.
Authors: Huber N; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Hietanen T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Heikkinen S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Shakirzyanova A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Hoffmann D; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Rostalski H; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Dhingra A; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Rodriguez-Nieto S; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Kärkkäinen S; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland., Koskuvi M; Neuroscience Center, University of Helsinki, Helsinki, Finland., Korhonen E; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Hartikainen P; Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland., Pylkäs K; Translational Medicine Research Unit, Medical Research Center Oulu and Biocenter Oulu, University of Oulu, and Northern Finland Laboratory Centre Nordlab, Oulu, Finland., Krüger J; Translational Medicine Research Unit, Medical Research Center Oulu and Biocenter Oulu, University of Oulu, and Northern Finland Laboratory Centre Nordlab, Oulu, Finland.; Research Unit of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.; Neurocenter, Neurology, Oulu University Hospital, Oulu, Finland.; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland., Malm T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Takalo M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Koistinaho J; Helsinki Institute of Life Science and Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland., Portaankorva AM; University of Helsinki, Helsinki, Finland., Solje E; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.; Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland., Haapasalo A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. annakaisa.haapasalo@uef.fi.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Mar; Vol. 31 (3), pp. 1500-1516. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03272-x