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Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.

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Title: Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.
Authors: Huber N; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Hietanen T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Heikkinen S; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Shakirzyanova A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Hoffmann D; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Rostalski H; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Dhingra A; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Rodriguez-Nieto S; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Kärkkäinen S; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland., Koskuvi M; Neuroscience Center, University of Helsinki, Helsinki, Finland., Korhonen E; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Hartikainen P; Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland., Pylkäs K; Translational Medicine Research Unit, Medical Research Center Oulu and Biocenter Oulu, University of Oulu, and Northern Finland Laboratory Centre Nordlab, Oulu, Finland., Krüger J; Translational Medicine Research Unit, Medical Research Center Oulu and Biocenter Oulu, University of Oulu, and Northern Finland Laboratory Centre Nordlab, Oulu, Finland.; Research Unit of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.; Neurocenter, Neurology, Oulu University Hospital, Oulu, Finland.; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland., Malm T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Takalo M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Koistinaho J; Helsinki Institute of Life Science and Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland., Portaankorva AM; University of Helsinki, Helsinki, Finland., Solje E; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.; Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland., Haapasalo A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. annakaisa.haapasalo@uef.fi.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Mar; Vol. 31 (3), pp. 1500-1516. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
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  Data: Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.
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  Data: <searchLink fieldCode="AU" term="%22Huber+N%22">Huber N</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Hietanen+T%22">Hietanen T</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Heikkinen+S%22">Heikkinen S</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Shakirzyanova+A%22">Shakirzyanova A</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Hoffmann+D%22">Hoffmann D</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Rostalski+H%22">Rostalski H</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Dhingra+A%22">Dhingra A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Nieto+S%22">Rodriguez-Nieto S</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kärkkäinen+S%22">Kärkkäinen S</searchLink>; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Koskuvi+M%22">Koskuvi M</searchLink>; Neuroscience Center, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Korhonen+E%22">Korhonen E</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Hartikainen+P%22">Hartikainen P</searchLink>; Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Pylkäs+K%22">Pylkäs K</searchLink>; Translational Medicine Research Unit, Medical Research Center Oulu and Biocenter Oulu, University of Oulu, and Northern Finland Laboratory Centre Nordlab, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Krüger+J%22">Krüger J</searchLink>; Translational Medicine Research Unit, Medical Research Center Oulu and Biocenter Oulu, University of Oulu, and Northern Finland Laboratory Centre Nordlab, Oulu, Finland.; Research Unit of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.; Neurocenter, Neurology, Oulu University Hospital, Oulu, Finland.; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Malm+T%22">Malm T</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Takalo+M%22">Takalo M</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Hiltunen+M%22">Hiltunen M</searchLink>; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Koistinaho+J%22">Koistinaho J</searchLink>; Helsinki Institute of Life Science and Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Portaankorva+AM%22">Portaankorva AM</searchLink>; University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Solje+E%22">Solje E</searchLink>; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.; Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Haapasalo+A%22">Haapasalo A</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. annakaisa.haapasalo@uef.fi.
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  Data: <searchLink fieldCode="JN" term="%229607835%22">Molecular psychiatry</searchLink> [Mol Psychiatry] 2026 Mar; Vol. 31 (3), pp. 1500-1516. <i>Date of Electronic Publication: </i>2025 Sep 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+Specialist+Journals%22">Nature Publishing Group Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607835 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5578 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213594184%22">13594184 </searchLink><i>NLM ISO Abbreviation: </i>Mol Psychiatry <i>Subsets: </i>MEDLINE
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