Rapid loss of activity but not serum concentration in a passive infusion clinical trial of an HIV neutralizing antibody.

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Title: Rapid loss of activity but not serum concentration in a passive infusion clinical trial of an HIV neutralizing antibody.
Authors: Mahomed S; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Medical Microbiology, University of Kwazulu-Natal, Durban, South Africa., Mkhize NN; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Serebryannyy LA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Hermanus T; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Kgagudi P; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Kaldine H; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Lambson B; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Narpala SR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Basappa M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Castro M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Lin BC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Carlton K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Sands JT; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Gall JG; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Morris L; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa., Karim QA; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA., Moore PL; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.; Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), a division of the National Health Laboratory Service, Johannesburg 2192, South Africa., Karim SA; Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA., Doria-Rose N; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Sep 07. Date of Electronic Publication: 2025 Sep 07.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.09.04.25334949